概述

  • 产品名称Anti-STXBP2抗体
    参阅全部 STXBP2 一抗
  • 描述
    兔多克隆抗体to STXBP2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow, Dog
  • 免疫原

    Recombinant protein fragment corresponding to a region within amino acids 151 and 341 of Human STXBP2 (NP_008880).

  • 阳性对照
    • HepG2 or HCT116 cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab97598 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 66 kDa.

靶标

  • 功能Involved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that regulate membrane fusion. Regulates cytotoxic granule exocytosis in natural killer (NK) cells.
  • 组织特异性Placenta, lung, liver, kidney and pancreas, as well as in peripheral blood lymphocytes.
  • 疾病相关Defects in STXBP2 are the cause of hemophagocytic lymphohistiocytosis familial type 5 (FHL5) [MIM:613101]. FHL5 is rare disorder characterized by immune dysregulation with hypercytokinemia, defective function of natural killer cell, and massive infiltration of several organs by activated lymphocytes and macrophages. The clinical features of the disease include fever, hepatosplenomegaly, cytopenia, and less frequently neurological abnormalities ranging from irritability and hypotonia to seizures, cranial nerve deficits and ataxia.
  • 序列相似性Belongs to the STXBP/unc-18/SEC1 family.
  • Information by UniProt
  • 数据库链接
  • 别名
    • FHL5 antibody
    • Hunc18b antibody
    • MUNC18 2 antibody
    • pp10122 antibody
    • Protein unc-18 homolog 2 antibody
    • Protein unc-18 homolog B antibody
    • STXB2_HUMAN antibody
    • Stxbp2 antibody
    • syntaxin binding protein 2 antibody
    • Syntaxin-binding protein 2 antibody
    • Unc-18B antibody
    • UNC18 2 antibody
    • Unc18-2 antibody
    • UNC18B antibody
    see all

Anti-STXBP2 antibody 图像

  • Anti-STXBP2 antibody (ab97598) at 1/1000 dilution + HCT116 whole cell lysate at 30 µg

    Predicted band size : 66 kDa

Anti-STXBP2 antibody (ab97598)参考文献

ab97598 has not yet been referenced specifically in any publications.

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