Anti-Stromal interaction molecule 1抗体[CDN3H4] (ab52458)

概述

  • 产品名称Anti-Stromal interaction molecule 1抗体[CDN3H4]
    参阅全部 Stromal interaction molecule 1 一抗
  • 描述
    小鼠单克隆抗体[CDN3H4] to Stromal interaction molecule 1
  • 经测试应用适用于: WB, IPmore details
  • 种属反应性
    与反应: Mouse, Rat
  • 免疫原

    Synthetic peptide corresponding to a C-terminal intracelullar portion of STIM1.

  • 阳性对照
    • RBL rat basophilic leukemia cell line

性能

应用

Our Abpromise guarantee covers the use of ab52458 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 77 kDa.
IP Use at an assay dependent dilution.

靶标

  • 功能Plays a role in mediating Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, TMEM142A/ORAI1.
  • 组织特异性Ubiquitously expressed in various human primary cells and tumor cell lines.
  • 疾病相关Defects in STIM1 are the cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 2 (IDTICED2) [MIM:612783]. IDTICED2 is an immune disorder characterized by recurrent infections, impaired T-cell activation and proliferative response, decreased T-cell production of cytokines, lymphadenopathy, and normal lymphocytes counts and serum immunoglobulin levels. Additional features include thrombocytopenia, autoimmune hemolytic anemia, non-progressive myopathy, partial iris hypoplasia, hepatosplenomegaly and defective enamel dentition.
  • 序列相似性Contains 1 EF-hand domain.
    Contains 1 SAM (sterile alpha motif) domain.
  • 结构域The microtubule tip localization signal (MtLS) motif; mediates interaction with MAPRE1 and targeting to the growing microtubule plus ends.
  • 翻译后修饰Glycosylation is required for cell surface expression.
    Phosphorylated predominantly on Ser residues.
  • 细胞定位Cell membrane. Endoplasmic reticulum membrane. Cytoplasm > cytoskeleton. Translocates from the endoplasmic reticulum to the cell membrane in response to a depletion of intracellular calcium. Associated with the microtubule network at the growing distal tip of microtubules.
  • Information by UniProt
  • 数据库链接
  • 别名
    • D11S4896E antibody
    • GOK antibody
    • OTTHUMP00000164512 antibody
    • OTTHUMP00000229140 antibody
    • OTTHUMP00000230742 antibody
    • SIM antibody
    • STIM 1 antibody
    • STIM1 antibody
    • Stim1 stromal interaction molecule 1 antibody
    • STIM1_HUMAN antibody
    • STIM1L antibody
    • Stromal interaction molecule 1 antibody
    see all

Anti-Stromal interaction molecule 1 antibody [CDN3H4] (ab52458)参考文献

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