Anti-Stromal interaction molecule 1抗体(ab123595)


  • 产品名称Anti-Stromal interaction molecule 1抗体
    参阅全部 Stromal interaction molecule 1 一抗
  • 描述
    兔多克隆抗体to Stromal interaction molecule 1
  • 经测试应用适用于: IPmore details
    不适用于: WB
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Horse, Dog, Chimpanzee, Gorilla, Chinese Hamster, Orangutan
  • 免疫原

    Synthetic peptide, corresponding to a region within amino acids 550-600 of Human Stromal interaction molecule 1 (NP_003147.2).

  • 阳性对照
    • HeLa whole cell lysate.



Our Abpromise guarantee covers the use of ab123595 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IP Use at 2-10 µg/mg of lysate.
  • 应用说明Is unsuitable for WB.
  • 靶标

    • 功能Plays a role in mediating Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, TMEM142A/ORAI1.
    • 组织特异性Ubiquitously expressed in various human primary cells and tumor cell lines.
    • 疾病相关Defects in STIM1 are the cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 2 (IDTICED2) [MIM:612783]. IDTICED2 is an immune disorder characterized by recurrent infections, impaired T-cell activation and proliferative response, decreased T-cell production of cytokines, lymphadenopathy, and normal lymphocytes counts and serum immunoglobulin levels. Additional features include thrombocytopenia, autoimmune hemolytic anemia, non-progressive myopathy, partial iris hypoplasia, hepatosplenomegaly and defective enamel dentition.
    • 序列相似性Contains 1 EF-hand domain.
      Contains 1 SAM (sterile alpha motif) domain.
    • 结构域The microtubule tip localization signal (MtLS) motif; mediates interaction with MAPRE1 and targeting to the growing microtubule plus ends.
    • 翻译后修饰Glycosylation is required for cell surface expression.
      Phosphorylated predominantly on Ser residues.
    • 细胞定位Cell membrane. Endoplasmic reticulum membrane. Cytoplasm > cytoskeleton. Translocates from the endoplasmic reticulum to the cell membrane in response to a depletion of intracellular calcium. Associated with the microtubule network at the growing distal tip of microtubules.
    • Information by UniProt
    • 数据库链接
    • 别名
      • D11S4896E antibody
      • GOK antibody
      • OTTHUMP00000164512 antibody
      • OTTHUMP00000229140 antibody
      • OTTHUMP00000230742 antibody
      • SIM antibody
      • STIM 1 antibody
      • STIM1 antibody
      • Stim1 stromal interaction molecule 1 antibody
      • STIM1_HUMAN antibody
      • STIM1L antibody
      • Stromal interaction molecule 1 antibody
      see all

    Anti-Stromal interaction molecule 1 antibody 图像

    • Detection of Stromal interaction molecule 1 by Western Blot of Immunprecipitate.
      anti-Stromal interaction molecule 1 antibody (recognizing a downstream epitope) at 1µg/ml staining Stromal interaction molecule 1 in HeLa whole cell lysate immunoprecipitated using ab123595 at 6µg/mg lysate (1 mg/IP; 20% of IP loaded/lane).
      Detection: Chemiluminescence with exposure time of 3 minutes.

    Anti-Stromal interaction molecule 1 antibody (ab123595)参考文献

    ab123595 has not yet been referenced specifically in any publications.

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