Anti-Stromal interaction molecule 1抗体(ab106531)


  • 产品名称Anti-Stromal interaction molecule 1抗体
    参阅全部 Stromal interaction molecule 1 一抗
  • 描述
    兔多克隆抗体to Stromal interaction molecule 1
  • 特异性At least two isoforms of Human STIM1 protein are known to exist. ab106531 will detect only the larger of the two isoforms. This STIM1 antibody is predicted to have no cross-reactivity to STIM2.
  • 经测试应用适用于: WB, ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide corresponding to a region near the carboxy terminus of Human Stromal interaction molecule 1.

  • 阳性对照
    • Human spleen tissue; Mouse thymus tissue lysate




Our Abpromise guarantee covers the use of ab106531 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 77 kDa.
ELISA 1/10000 - 1/40000.
IHC-P Use a concentration of 2.5 µg/ml.


  • 功能Plays a role in mediating Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, TMEM142A/ORAI1.
  • 组织特异性Ubiquitously expressed in various human primary cells and tumor cell lines.
  • 疾病相关Defects in STIM1 are the cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 2 (IDTICED2) [MIM:612783]. IDTICED2 is an immune disorder characterized by recurrent infections, impaired T-cell activation and proliferative response, decreased T-cell production of cytokines, lymphadenopathy, and normal lymphocytes counts and serum immunoglobulin levels. Additional features include thrombocytopenia, autoimmune hemolytic anemia, non-progressive myopathy, partial iris hypoplasia, hepatosplenomegaly and defective enamel dentition.
  • 序列相似性Contains 1 EF-hand domain.
    Contains 1 SAM (sterile alpha motif) domain.
  • 结构域The microtubule tip localization signal (MtLS) motif; mediates interaction with MAPRE1 and targeting to the growing microtubule plus ends.
  • 翻译后修饰Glycosylation is required for cell surface expression.
    Phosphorylated predominantly on Ser residues.
  • 细胞定位Cell membrane. Endoplasmic reticulum membrane. Cytoplasm > cytoskeleton. Translocates from the endoplasmic reticulum to the cell membrane in response to a depletion of intracellular calcium. Associated with the microtubule network at the growing distal tip of microtubules.
  • Information by UniProt
  • 数据库链接
  • 别名
    • D11S4896E antibody
    • GOK antibody
    • OTTHUMP00000164512 antibody
    • OTTHUMP00000229140 antibody
    • OTTHUMP00000230742 antibody
    • SIM antibody
    • STIM 1 antibody
    • STIM1 antibody
    • Stim1 stromal interaction molecule 1 antibody
    • STIM1_HUMAN antibody
    • STIM1L antibody
    • Stromal interaction molecule 1 antibody
    see all

Anti-Stromal interaction molecule 1 antibody 图像

  • Lane 1 : Anti-Stromal interaction molecule 1 antibody (ab106531) at 1 µg/ml
    Lane 2 : Anti-Stromal interaction molecule 1 antibody (ab106531) at 2 µg/ml

    Lane 1 : Mouse thymus tissue lysate
    Lane 2 : Mouse thymus tissue lysate

    Predicted band size : 77 kDa
  • ab106531, at 2.5 µg/ml, staining STIM1 in Human spleen tissue by Immunohistochemistry.

Anti-Stromal interaction molecule 1 antibody (ab106531)参考文献

This product has been referenced in:

See 1 Publication for this product

Product Wall

There are currently no Abreviews or Questions for ab106531.
Please use the links above to contact us or submit feedback about this product.