Binds to the capsular antigens of S pneumoniae.
Antigenic factors of S pneumoniae are shared widely with other bacteria. It is important to identify the specimen as S pneumoniae by biochemical methods.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at an assay dependent concentration.
See attached protocol.
Streptococcus pneumoniae is the most common cause of community-acquired bacterial pneumonia (CAP), and otis media, and the second most common cause of meninigitis in infants and children, which may lead to learning disabilities and hearing impairment. Mortality occurs in ~10-15% of hospitalized adults with invasive disease. While a licensed 23-valent-polysaccharide vaccine in now available, widespread overuse of antibiotics has contributed to the emergence of drug resistant strains. Streptococcus pneumoniae is serotyped baseed on the antigenicity of the capsular polysaccharide.