概述

  • 产品名称Anti-STIM2抗体
    参阅全部 STIM2 一抗
  • 描述
    兔多克隆抗体to STIM2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within N terminal amino acids 97-127 of Human STIM2 (NP_001162589.1, NP_065911.3, NP_001162588.1).

  • 阳性对照
    • UM cell line lysates.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • 存储溶液Preservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明ab112963 is purified through a protein A column, followed by peptide affinity purification.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab112963 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 84 kDa.

靶标

  • 功能Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx.
  • 组织特异性Expressed in all tissues and tumor cell lines examined.
  • 序列相似性Contains 1 EF-hand domain.
    Contains 1 SAM (sterile alpha motif) domain.
  • 翻译后修饰Glycosylated.
    Phosphorylated predominantly on Ser residues.
  • 细胞定位Endoplasmic reticulum membrane. Dynamically translocates from a uniform endoplasmic reticulum distribution to punctual endoplasmic reticulum-plasma membrane junctions in response to decrease in endoplasmic reticulum Ca(2+) concentration.
  • Information by UniProt
  • 数据库链接
  • 别名
    • FLJ39527 antibody
    • KIAA1482 antibody
    • STIM 2 antibody
    • STIM2 antibody
    • STIM2_HUMAN antibody
    • Stromal interaction molecule 2 antibody
    see all

Anti-STIM2 antibody 图像

  • Anti-STIM2 antibody (ab112963) at 1/100 dilution + UM cell line lysate at 35 µg

    Predicted band size : 84 kDa

Anti-STIM2 antibody (ab112963)参考文献

ab112963 has not yet been referenced specifically in any publications.

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