概述

  • 产品名称Anti-Stefin B抗体
    参阅全部 Stefin B 一抗
  • 描述
    小鼠单克隆抗体to Stefin B
  • 经测试应用适用于: WB, IHC-P, IHC-Fr, ICC/IFmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant full length protein: MMCGAPSATQ PATAETQHIA DQVRSQLEEK ENKKFPVFKA VSFKSQVVAG TNYFIKVHVG DEDFVHLRVF QSLPHENKPL TLSNYQTNKA KHDELTYF, corresponding to amino acids 1-297 of Human Stefin B

性能

应用

Our Abpromise guarantee covers the use of ab54566 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
IHC-P
IHC-Fr
ICC/IF
  • 应用说明ICC/IF: Use at a concentration of 10 µg/ml.
    IHC-P: Use at a concentration of 5 µg/ml.
    IHC-Fr: Use at an assay dependent dilution (PMID 19188175).
    WB: Use at a concentration of 1 - 5 µg/ml. Predicted molecular weight: 11 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能This is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B.
    • 疾病相关Defects in CSTB are the cause of progressive myoclonic epilepsy type 1 (EPM1) [MIM:254800]. EPM1 is an autosomal recessive disorder characterized by severe, stimulus-sensitive myoclonus and tonic-clonic seizures. The onset, occurring between 6 and 13 years of age, is characterized by convulsions. Myoclonus begins 1 to 5 years later. The twitchings occur predominantly in the proximal muscles of the extremities and are bilaterally symmetrical, although asynchronous. At first small, they become late in the clinical course so violent that the victim is thrown to the floor. Mental deterioration and eventually dementia develop.
    • 序列相似性Belongs to the cystatin family.
    • 细胞定位Cytoplasm. Nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • CHROW21 antibody
      • CPI B antibody
      • CPI-B antibody
      • CST 6 antibody
      • CST6 antibody
      • CSTB antibody
      • Cystatin B (stefin B) antibody
      • Cystatin B antibody
      • Cystatin-B antibody
      • CYTB antibody
      • CYTB_HUMAN antibody
      • EPM1 antibody
      • EPM1A antibody
      • Liver thiol proteinase inhibitor antibody
      • PME antibody
      • Stefin-B antibody
      • STF B antibody
      • STFB antibody
      • ULD antibody
      see all

    Anti-Stefin B antibody 图像

    • Stefin B antibody (ab54566) used in immunohistochemistry at 5ug/ml on formalin fixed and paraffin embedded human colon tissue.


    • Predicted band size : 11 kDa
    • ab54566 at 10 µg/ml staining Stefin B in A-431 cells by Immunocytochemistry / Immunofluorescence.

    Anti-Stefin B antibody (ab54566)参考文献

    This product has been referenced in:
    • Feldman AS  et al. Cystatin B as a tissue and urinary biomarker of bladder cancer recurrence and disease progression. Clin Cancer Res 15:1024-31 (2009). IHC-Fr ; Human . Read more (PubMed: 19188175) »

    See 1 Publication for this product

    Product Wall

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"