Anti-STEAP1抗体(ab3679)

概述

  • 产品名称Anti-STEAP1抗体
    参阅全部 STEAP1 一抗
  • 描述
    兔多克隆抗体to STEAP1
  • 特异性This antibody reacts predominantly with STEAP. Ab3679 can be used as a plasma marker for prostate cancer cells
  • 经测试应用适用于: WB, IP, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide:

    WKMKPRRNLEEDDYL

    , corresponding to amino acids 14-28 of Human STEAP.

  • 阳性对照
    • WB: A431 cell lysate
  • 常规说明


    Prostate cancer is the most frequently diagnosed cancer and is the second leading cause of cancer-related deaths in American men. Although the early serum detection of prostate-specific antigen (PSA) plays important roles in early diagnosis, it may not distinguish prostate cancer from benign diseases. Recently, a novel protein, which contains 339 amino acids, named STEAP (six transmembrane epithelial antigen of the prostate), was identified in advanced prostate cancer. STEAP is unique among the currently known prostate cancer markers because of its putative secondary structure, from which one may predict that it functions as a potential channel protein. STEAP is strongly expressed in advanced prostate cancer and some extent expression in other cancers, such as colon and ovarian cancer cell lines.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液PBS with 0.02% sodium azide
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • Primary antibody说明Prostate cancer is the most frequently diagnosed cancer and is the second leading cause of cancer-related deaths in American men. Although the early serum detection of prostate-specific antigen (PSA) plays important roles in early diagnosis, it may not distinguish prostate cancer from benign diseases. Recently, a novel protein, which contains 339 amino acids, named STEAP (six transmembrane epithelial antigen of the prostate), was identified in advanced prostate cancer. STEAP is unique among the currently known prostate cancer markers because of its putative secondary structure, from which one may predict that it functions as a potential channel protein. STEAP is strongly expressed in advanced prostate cancer and some extent expression in other cancers, such as colon and ovarian cancer cell lines.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

相关产品

应用

Our Abpromise guarantee covers the use of ab3679 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.5 - 2 µg/ml. Detects a band of approximately 40 kDa (predicted molecular weight: 38 kDa).
IP Use at an assay dependent dilution.
ELISA Use at an assay dependent dilution.

靶标

  • 功能Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor.
  • 组织特异性Ubiquitously expressed. Highly expressed in prostate tumors.
  • 序列相似性Belongs to the STEAP family.
    Contains 1 ferric oxidoreductase domain.
  • 细胞定位Endosome membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 2410007B19Rik antibody
    • EC 1.16.1.- antibody
    • Metalloreductase STEAP1 antibody
    • MGC19484 antibody
    • PRSS 24 antibody
    • PRSS24 antibody
    • Six transmembrane epithelial antigen of prostate antibody
    • Six transmembrane epithelial antigen of the prostate 1 antibody
    • Six transmembrane epithelial antigen of the prostate antibody
    • Six-transmembrane epithelial antigen of prostate 1 antibody
    • STEA1_HUMAN antibody
    • STEAP 1 antibody
    • Steap antibody
    • STEAP1 antibody
    see all

Anti-STEAP1 antibody 图像



  • Predicted band size : 38 kDa


    A431 cell lysate probed with anti-STEAP (ab3679) at 1 microgram/ml

Anti-STEAP1 antibody (ab3679)参考文献

ab3679 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"