概述

  • 产品名称
    Anti-Staufen抗体
    参阅全部 Staufen 一抗
  • 描述
    兔多克隆抗体to Staufen
  • 特异性
    At least three isoforms of Staufen are known to exist; ab105398 will detect all three.
  • 经测试应用
    适用于: ICC/IF, WB, ICCmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    A 15 amino acid synthetic peptide from near the carboxy terminus of Human Staufen (NP_059347).(Peptide available as ab110446.)

  • 阳性对照
    • Rat brain tissue lysate.

性能

应用

Our Abpromise guarantee covers the use of ab105398 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 63 kDa.Can be blocked with Staufen peptide (ab110446).
ICC Use a concentration of 10 µg/ml.

靶标

  • 功能
    Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site.
  • 组织特异性
    Widely expressed. Expressed in brain, pancreas, heart, skeletal muscles, liver, lung, kidney and placenta.
  • 序列相似性
    Contains 3 DRBM (double-stranded RNA-binding) domains.
  • 结构域
    One of the DRDB could be involved in RER binding.
    The C-terminal contains the tubulin binding domain (TBD).
  • 细胞定位
    Cytoplasm. Rough endoplasmic reticulum. Localizes exclusively with the rough reticulum endoplasmic.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Double stranded RNA binding protein Staufen homolog 1 antibody
    • Double stranded RNA binding protein Staufen homolog antibody
    • Double-stranded RNA-binding protein Staufen homolog 1 antibody
    • FLJ25010 antibody
    • MGC124588 antibody
    • PPP1R150 antibody
    • STAU antibody
    • STAU1 antibody
    • STAU1_HUMAN antibody
    • staufen antibody
    • Staufen RNA binding protein (Drosophila) antibody
    • Staufen RNA binding protein homolog 1 antibody
    • Staufen, Drosophila, homolog of, 1 antibody
    • Staufen, RNA binding protein, homolog 1 (Drosophila) antibody
    • staufen-like antibody
    see all

图片

  • Lane 1 : Anti-Staufen antibody (ab105398) at 1 µg/ml
    Lane 2 : Anti-Staufen antibody (ab105398) at 2 µg/ml

    Lane 1 : Rat brain tissue lysate
    Lane 2 : Rat brain tissue lysate

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 63 kDa
  • Immunohistochemistry of Staufen in Human brain tissue with ab105398 at 10 µg/ml.
  • Immunofluorescence of STAU1 in Human Brain cells using ab105398 at 20 ug/ml.

文献

ab105398 has not yet been referenced specifically in any publications.

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