Stattic,STAT3抑制剂(ab120952)
Key features and details
- Selective STAT3 inhibitor
- CAS Number: 19983-44-9
- Purity: > 99%
- Soluble in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
Stattic,STAT3抑制剂 -
描述
Selective STAT3抑制剂 -
纯度
> 99% -
CAS编号
19983-44-9 -
化学结构
性能
-
化学名称
6-Nitrobenzo[b]thiophene-1,1-dioxide -
分子量
211.19 -
分子式
C8H5NO4S -
PubChem识别号
2779853 -
存放说明
Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions. -
溶解度概述
Soluble in DMSO to 50 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
[O-][N+](=O)c1ccc2C=CS(=O)(=O)c2c1 -
来源
Synthetic
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研究领域
- Biochemicals
- Research Area
- Alzheimer's Disease
- Signaling
- Signal transduction
- JAK/STAT signaling
- STAT
- Inhibitors
- Biochemicals
- Research Area
- Diabetes
- Signaling
- Signal transduction
- JAK/STAT signaling
- STAT
- Inhibitors
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab120952于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
Functional Studies |
Use at an assay dependent concentration.
|
说明 |
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Functional Studies
Use at an assay dependent concentration. |
图片
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2D chemical structure image of ab120952, Stattic, STAT3 inhibitor
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ab76315 staining STAT3 (phospho Y705) in MDA-MB-231 cells treated with stattic (ab120952), by ICC/IF. Decrease in STAT3 (phospho Y705) expression correlates with increased concentration of stattic as described in literature.
The cells were incubated at 37°C for 2h in media containing different concentrations of ab120952 (stattic) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab76315 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (29)
ab120952 被引用在 29 文献中.
- Liu B et al. Cationic amphiphilic antihistamines inhibit STAT3 via Ca2+-dependent lysosomal H+ efflux. Cell Rep 42:112137 (2023). PubMed: 36807142
- Jafari S et al. Silibinin induces immunogenic cell death in cancer cells and enhances the induced immunogenicity by chemotherapy. Bioimpacts 13:51-61 (2023). PubMed: 36816998
- Wiedmann L et al. HAPLN1 potentiates peritoneal metastasis in pancreatic cancer. Nat Commun 14:2353 (2023). PubMed: 37095087
- Takata J et al. Chemo-preventive effects and antitumorigenic mechanisms of beer and nonalcoholic beer toward 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) - induced lung tumorigenesis in A/J mice. Genes Environ 45:19 (2023). PubMed: 37280663
- Mantsounga CS et al. Macrophage IL-1ß promotes arteriogenesis by autocrine STAT3- and NF-?B-mediated transcription of pro-angiogenic VEGF-A. Cell Rep 38:110309 (2022). PubMed: 35108537