概述

  • 产品名称
  • 描述
    羊多克隆抗体to STAT5b
  • 经测试应用
    适用于: IPmore details
  • 种属反应性
    与反应: Mouse, Human
    预测可用于: Rat, Chicken, Cow, Pig, Xenopus laevis, Cynomolgus monkey
  • 免疫原

    Synthetic peptide:

    CMDSQWIPHAQS

    , corresponding to C terminal amino acids 777-787 of Human STAT5b conjugated to KLH

  • 阳性对照
    • Rat liver lysate.

性能

应用

Our Abpromise guarantee covers the use of ab65743 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IP Use at 2 µg/mg of lysate.

靶标

  • 功能
    Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription.
  • 疾病相关
    Growth hormone insensitivity with immunodeficiency
  • 序列相似性
    Belongs to the transcription factor STAT family.
    Contains 1 SH2 domain.
  • 翻译后修饰
    Tyrosine phosphorylated in response to signaling via activated KIT, resulting in translocation to the nucleus. Tyrosine phosphorylated in response to signaling via activated FLT3; wild-type FLT3 results in much weaker phosphorylation than constitutively activated mutant FLT3. Alternatively, can be phosphorylated by JAK2. Phosphorylation at Tyr-699 by PTK6 or HCK leads to an increase of its transcriptional activity. Dephosphorylation on tyrosine residues by PTPN2 negatively regulates prolactin signaling pathway.
  • 细胞定位
    Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Signal transducer and activator of transcription 5B antibody
    • STA5B_HUMAN antibody
    • STAT5 antibody
    • Stat5b antibody
    • Transcription factor STAT5B antibody
    see all

图片

  • Immunoprecipitation of ab65743 (2µg/mg lysate) with rat liver lysate using protein G beads (lane 1), and controls using beads alone (lane 2). Western blot analysis by another commercially available STAT5b antibody.

文献

This product has been referenced in:
  • Elliott S  et al. Lack of expression and function of erythropoietin receptors in the kidney. Nephrol Dial Transplant : (2011). IP ; Human . Read more (PubMed: 22167585) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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