概述

  • 产品名称
  • 描述
    羊多克隆抗体to STAT5a
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Rat, Hamster, Human
    预测可用于: Sheep
  • 免疫原

    Synthetic peptide:

    CGLFTSARGSLS

    , corresponding to C terminal amino acids 784-794 of Human STAT5a conjugated to KLH

  • 阳性对照
    • CHO-IR cell extracts.

性能

应用

Our Abpromise guarantee covers the use of ab65742 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 2 µg/ml. Detects a band of approximately 91 kDa (predicted molecular weight: 91 kDa).

靶标

  • 功能
    Carries out a dual function: signal transduction and activation of transcription. Binds to the GAS element and activates PRL-induced transcription.
  • 序列相似性
    Belongs to the transcription factor STAT family.
    Contains 1 SH2 domain.
  • 翻译后修饰
    Tyrosine phosphorylated in response to IL-2, IL-3, IL-7, IL-15, GM-CSF, growth hormone, prolactin, erythropoietin and thrombopoietin. Tyrosine phosphorylation is required for DNA-binding activity and dimerization. Serine phosphorylation is also required for maximal transcriptional activity.
  • 细胞定位
    Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Mammary gland factor antibody
    • MGF antibody
    • Signal transducer and activator of transcription 5A antibody
    • STA5A_HUMAN antibody
    • STAT 5 antibody
    • STAT 5A antibody
    • STAT5 antibody
    • STAT5A antibody
    see all

图片

  • Anti-STAT5a antibody (ab65742) at 2 µg/ml + CHO-IR cell extracts

    Predicted band size : 91 kDa
    Observed band size : 91 kDa

实验方案

文献

ab65742 has not yet been referenced specifically in any publications.

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