概述

  • 产品名称Anti-STAT5a抗体
    参阅全部 STAT5a 一抗
  • 描述
    兔多克隆抗体to STAT5a
  • 经测试应用适用于: WB, IPmore details
  • 种属反应性
    与反应: Mouse, Human
    预测可用于: Rat
  • 免疫原

    Synthetic peptide:

    CRLSPPAGLFTSARGSLS

    conjugated to KLH, corresponding to amino acids 778-794 of Human STAT5a.

  • 阳性对照
    • Mouse 3T3 cell lysate.
  • 常规说明If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use.

性能

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应用

Our Abpromise guarantee covers the use of ab12195 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 95 kDa.
IP Use at 4 µg/mg of lysate.

靶标

  • 功能Carries out a dual function: signal transduction and activation of transcription. Binds to the GAS element and activates PRL-induced transcription.
  • 序列相似性Belongs to the transcription factor STAT family.
    Contains 1 SH2 domain.
  • 翻译后修饰Tyrosine phosphorylated in response to IL-2, IL-3, IL-7, IL-15, GM-CSF, growth hormone, prolactin, erythropoietin and thrombopoietin. Tyrosine phosphorylation is required for DNA-binding activity and dimerization. Serine phosphorylation is also required for maximal transcriptional activity.
  • 细胞定位Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Mammary gland factor antibody
    • MGF antibody
    • Signal transducer and activator of transcription 5A antibody
    • STA5A_HUMAN antibody
    • STAT 5 antibody
    • STAT 5A antibody
    • STAT5 antibody
    • STAT5A antibody
    see all

Anti-STAT5a antibody (ab12195)参考文献

This product has been referenced in:
  • Elliott S  et al. Lack of expression and function of erythropoietin receptors in the kidney. Nephrol Dial Transplant : (2011). IP ; Human . Read more (PubMed: 22167585) »

See 1 Publication for this product

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