概述

  • 产品名称Anti-STAT5抗体
    参阅全部 STAT5 一抗
  • 描述
    兔多克隆抗体to STAT5
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Sheep, Cow
  • 免疫原

    Synthetic peptide conjugated to KLH derived from within residues 1 - 100 of Human STAT5.

    (Peptide available as ab99165.)

  • 阳性对照
    • This antibody gave a positive signal in the following whole cell lysates: MCF7; Jurkat.

性能

应用

Our Abpromise guarantee covers the use of ab88246 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Detects a band of approximately 90 kDa (predicted molecular weight: 90 kDa).

靶标

  • 功能Carries out a dual function: signal transduction and activation of transcription. Binds to the GAS element and activates PRL-induced transcription.
  • 序列相似性Belongs to the transcription factor STAT family.
    Contains 1 SH2 domain.
  • 翻译后修饰Tyrosine phosphorylated in response to IL-2, IL-3, IL-7, IL-15, GM-CSF, growth hormone, prolactin, erythropoietin and thrombopoietin. Tyrosine phosphorylation is required for DNA-binding activity and dimerization. Serine phosphorylation is also required for maximal transcriptional activity.
  • 细胞定位Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation.
  • Information by UniProt
  • 数据库链接
  • 别名
    • MGF antibody
    • Signal transducer and activator of transcription 5A antibody
    • Signal Transducer and Activator of Transcription 5B antibody
    • STA5A_HUMAN antibody
    • STAT 5A antibody
    • STAT 5B antibody
    • STAT5 antibody
    • STAT5A antibody
    • STAT5B antibody
    • Transcription factor STAT5A antibody
    • Transcription factor STAT5B antibody
    see all

Anti-STAT5 antibody 图像

  • All lanes : Anti-STAT5 antibody (ab88246) at 1 µg/ml

    Lane 1 : MCF7 (Human breast adenocarcinoma cell line) Whole Cell Lysate
    Lane 2 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell Lysate

    Lysates/proteins at 10 µg per lane.

    Secondary
    Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution
    Developed using the ECL technique

    Performed under reducing conditions.

    Predicted band size : 90 kDa
    Observed band size : 90 kDa
    Additional bands at : 140 kDa,68 kDa. We are unsure as to the identity of these extra bands.

Anti-STAT5 antibody (ab88246)参考文献

ab88246 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab88246.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"