Anti-STAT5抗体(ab126832)
Key features and details
- Rabbit polyclonal to STAT5
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-STAT5抗体
参阅全部 STAT5 一抗 -
描述
兔多克隆抗体to STAT5 -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human -
免疫原
Synthetic peptide:
DGYVK
, corresponding to amino acids 692-696 of Human STAT5 (UniProt P42229). -
阳性对照
- Human recombinant STAT5 protein; K562 cell lysate.
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常规说明
For storage at 4°C for several months add 0.1% NaN3.The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
存储溶液
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 49% PBS, 50% Glycerol (glycerin, glycerine) -
Concentration information loading...
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纯度
Protein A purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab126832于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/1000. Predicted molecular weight: 91 kDa.
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说明 |
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WB
1/1000. Predicted molecular weight: 91 kDa. |
靶标
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功能
Carries out a dual function: signal transduction and activation of transcription. Binds to the GAS element and activates PRL-induced transcription. -
序列相似性
Belongs to the transcription factor STAT family.
Contains 1 SH2 domain. -
翻译后修饰
Tyrosine phosphorylated in response to IL-2, IL-3, IL-7, IL-15, GM-CSF, growth hormone, prolactin, erythropoietin and thrombopoietin. Tyrosine phosphorylation is required for DNA-binding activity and dimerization. Serine phosphorylation is also required for maximal transcriptional activity. -
细胞定位
Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation. - Information by UniProt
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数据库链接
- Entrez Gene: 6776 Human
- Entrez Gene: 6777 Human
- Omim: 601511 Human
- Omim: 604260 Human
- SwissProt: P42229 Human
- SwissProt: P51692 Human
- Unigene: 437058 Human
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别名
- MGF antibody
- Signal transducer and activator of transcription 5A antibody
- Signal Transducer and Activator of Transcription 5B antibody
see all
图片
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All lanes : Anti-STAT5 antibody (ab126832) at 1/1000 dilution
Lane 1 : Human recombinant STAT1 beta
Lane 2 : Human recombinant STAT2
Lane 3 : Human recombinant STAT3
Lane 4 : Human recombinant STAT4
Lane 5 : Human recombinant STAT5
Lane 6 : Human recombinant STAT6
Lysates/proteins at 0.005 µg per lane.
Predicted band size: 91 kDa -
All lanes : Anti-STAT5 antibody (ab126832) at 1/1000 dilution
Lane 1 : K562 cell lysate at 3 µg
Lane 2 : K562 cell lysate at 10 µg
Lane 3 : K562 cell lysate at 30 µg
Predicted band size: 91 kDa
数据表及文件
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SDS download
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Datasheet download
文献 (2)
ab126832 被引用在 2 文献中.
- Jiang S et al. Stimulation of Prostate Cells by the Senescence Phenotype of Epithelial and Stromal Cells: Implication for Benign Prostate Hyperplasia. FASEB Bioadv 1:353-363 (2019). PubMed: 31844843
- Ma H et al. STAT5 and TET2 Cooperate to Regulate FOXP3-TSDR Demethylation in CD4+ T Cells of Patients with Colorectal Cancer. J Immunol Res 2018:6985031 (2018). PubMed: 30013992