Anti-STAT2 (phospho Y631)抗体(ab111609)

概述

  • 产品名称Anti-STAT2 (phospho Y631)抗体
    参阅全部 STAT2 一抗
  • 描述
    兔多克隆抗体to STAT2 (phospho Y631)
  • 特异性ab111609 detects endogenous levels of STAT2 only when phosphorylated at tyrosine 631.
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Synthetic phosphopeptide derived from Human STAT2 around the phosphorylation site of tyrosine 631 (Q-P-YP-T-K).

  • 阳性对照
    • Human colon carcinoma tissue.

性能

应用

Our Abpromise guarantee covers the use of ab111609 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
  • 序列相似性Belongs to the transcription factor STAT family.
    Contains 1 SH2 domain.
  • 翻译后修饰Tyrosine phosphorylated in response to IFN-alpha.
  • 细胞定位Cytoplasm. Nucleus. Translocated into the nucleus upon activation by IFN-alpha/beta.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Homo sapiens interferon alpha induced transcriptional activator antibody
    • interferon alpha induced transcriptional activator antibody
    • ISGF 3 antibody
    • ISGF3 antibody
    • MGC59816 antibody
    • P113 antibody
    • signal transducer and activator of transcription 2 113kD antibody
    • Signal transducer and activator of transcription 2 antibody
    • STAT113 antibody
    • Stat2 antibody
    • STAT2_HUMAN antibody
    see all

Anti-STAT2 (phospho Y631) antibody 图像

  • ab111609 at 1/50 dilution staining STAT2 in paraffin-embedded Human Colon carcinoma tissue by Immunohistochemistry. The image on the right is treated with the synthesized phosphopeptide.

Anti-STAT2 (phospho Y631) antibody (ab111609)参考文献

ab111609 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your enquiry.

Here is the link for the activated Stat1 reference we discussed:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060772/?tool=pubmed

It uses the following antibody, ab4742:

http://www.abc...

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I am sorry this product did not perform as stated on the datasheet and for the inconvenience this has caused. As requested, I have issued a free of charge replacement for one vial of ab111609.


As we discussed, this antibody is backorder...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"