RabMAb

Anti-STAT2抗体[Y141] (ab32367)

概述

  • 产品名称Anti-STAT2抗体[Y141]
    参阅全部 STAT2 一抗
  • 描述
    兔单克隆抗体[Y141] to STAT2
  • 特异性This antibody detects both long and short forms of STAT2.
  • 经测试应用适用于: WB, ICC, IHC-Pmore details
    不适用于: Flow Cyt or IP
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    A synthetic peptide corresponding to residues near N-terminus of human Stat-2.

  • 阳性对照
    • K562 cell lysate and human thyroid cancer
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

     

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab32367 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/5000 - 1/10000. Detects a band of approximately 98 kDa (predicted molecular weight: 98 kDa).
ICC 1/50 - 1/100.
IHC-P 1/100 - 1/250.
  • 应用说明Is unsuitable for Flow Cyt or IP.
  • 靶标

    • 功能Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
    • 序列相似性Belongs to the transcription factor STAT family.
      Contains 1 SH2 domain.
    • 翻译后修饰Tyrosine phosphorylated in response to IFN-alpha.
    • 细胞定位Cytoplasm. Nucleus. Translocated into the nucleus upon activation by IFN-alpha/beta.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Homo sapiens interferon alpha induced transcriptional activator antibody
      • interferon alpha induced transcriptional activator antibody
      • ISGF 3 antibody
      • ISGF3 antibody
      • MGC59816 antibody
      • P113 antibody
      • signal transducer and activator of transcription 2 113kD antibody
      • Signal transducer and activator of transcription 2 antibody
      • STAT113 antibody
      • Stat2 antibody
      • STAT2_HUMAN antibody
      see all

    Anti-STAT2 antibody [Y141] 图像

    • Anti-STAT2 antibody [Y141] (ab32367) at 1/500 dilution + K562 cell lysate

      Predicted band size : 98 kDa
      Observed band size : 100 kDa (why is the actual band size different from the predicted?)
    • Immunohistochemical analysis of paraffin-embedded human thyroid cancer using ab32367

    Anti-STAT2 antibody [Y141] (ab32367)参考文献

    ab32367 has not yet been referenced specifically in any publications.

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