概述

  • 产品名称Anti-STAT2抗体
    参阅全部 STAT2 一抗
  • 描述
    兔多克隆抗体to STAT2
  • 经测试应用适用于: IPmore details
    不适用于: WB
  • 种属反应性
    与反应: Human
    预测可用于: Chimpanzee, Gorilla, Orangutan
  • 免疫原

    Synthetic peptide, corresponding to a region within amino acids 175-225 of Human STAT2 (NP_005410.1).

  • 阳性对照
    • Jurkat whole cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab124283 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IP Use at 2-10 µg/mg of lysate.
  • 应用说明Is unsuitable for WB.
  • 靶标

    • 功能Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
    • 序列相似性Belongs to the transcription factor STAT family.
      Contains 1 SH2 domain.
    • 翻译后修饰Tyrosine phosphorylated in response to IFN-alpha.
    • 细胞定位Cytoplasm. Nucleus. Translocated into the nucleus upon activation by IFN-alpha/beta.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Homo sapiens interferon alpha induced transcriptional activator antibody
      • interferon alpha induced transcriptional activator antibody
      • ISGF 3 antibody
      • ISGF3 antibody
      • MGC59816 antibody
      • P113 antibody
      • signal transducer and activator of transcription 2 113kD antibody
      • Signal transducer and activator of transcription 2 antibody
      • STAT113 antibody
      • Stat2 antibody
      • STAT2_HUMAN antibody
      see all

    Anti-STAT2 antibody 图像

    • Detection of STAT2 by Western Blot of Immunprecipitate.
      anti-STAT2 antibody at 1µg/ml staining STAT2 in Jurkat whole cell lysate immunoprecipitated using ab123283 at 6µg/mg lysate (1 mg/IP; 20% of IP loaded/lane).
      Detection: Chemiluminescence with exposure time of 3 seconds.

    Anti-STAT2 antibody (ab124283)参考文献

    ab124283 has not yet been referenced specifically in any publications.

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