Anti-STAT2抗体[19G8.H2.H6] (ab106094)

概述

  • 产品名称Anti-STAT2抗体[19G8.H2.H6]
    参阅全部 STAT2 一抗
  • 描述
    小鼠单克隆抗体[19G8.H2.H6] to STAT2
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    A synthetic peptide corresponding to residues near the carboxy terminus of mouse STAT2 protein.

  • 阳性对照
    • HeLa whole cell lysate; Human skin tissue (squamous epithelium).
  • 常规说明Expiration date is one year from date of opening.

性能

应用

Our Abpromise guarantee covers the use of ab106094 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000. Predicted molecular weight: 98 kDa.
IHC-P Use a concentration of 2.5 µg/ml.

靶标

  • 功能Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
  • 序列相似性Belongs to the transcription factor STAT family.
    Contains 1 SH2 domain.
  • 翻译后修饰Tyrosine phosphorylated in response to IFN-alpha.
  • 细胞定位Cytoplasm. Nucleus. Translocated into the nucleus upon activation by IFN-alpha/beta.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Homo sapiens interferon alpha induced transcriptional activator antibody
    • interferon alpha induced transcriptional activator antibody
    • ISGF 3 antibody
    • ISGF3 antibody
    • MGC59816 antibody
    • P113 antibody
    • signal transducer and activator of transcription 2 113kD antibody
    • Signal transducer and activator of transcription 2 antibody
    • STAT113 antibody
    • Stat2 antibody
    • STAT2_HUMAN antibody
    see all

Anti-STAT2 antibody [19G8.H2.H6] 图像

  • Anti-STAT2 antibody [19G8.H2.H6] (ab106094) at 1/1000 dilution + HeLa whole cell lysate at 1 µg

    Predicted band size : 98 kDa
  • ab106094 at 2.5µg/ml staining STAT2 in Formalin fixed, Paraffin-embedded Human Skin (squamous epithelium) by Immunohistochemistry. Note: moderate to strong nuclear and faint to moderate cytoplasmic staining.
    The image shows the localization of the antibody as the precipitated red signal, with a hematoxylin purple nuclear counterstain.

Anti-STAT2 antibody [19G8.H2.H6] (ab106094)参考文献

ab106094 has not yet been referenced specifically in any publications.

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