概述

  • 产品名称Anti-StAR抗体
    参阅全部 StAR 一抗
  • 描述
    兔多克隆抗体to StAR
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
    预测可用于: Cow, Dog, Pig
  • 免疫原

    Recombinant protein fragment corresponding to a region within amino acids 15 - 238 of Human StAR (NP_000340).

  • 阳性对照
    • 293T, A431, HeLa, HepG2, MOLT4 and Raji cell lysates

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab96637 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 32 kDa.

靶标

  • 功能Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.
  • 组织特异性Expressed in gonads, adrenal cortex and kidney.
  • 通路Steroid metabolism; cholesterol metabolism.
  • 疾病相关Defects in STAR are the cause of adrenal hyperplasia type 1 (AH1) [MIM:201710]. The most severe form of adrenal hyperplasia. It is a condition characterized by onset of profound adrenocortical insufficiency shortly after birth, hyperpigmentation reflecting increased production of pro-opiomelanocortin, elevated plasma renin activity as a consequence of reduced aldosterone synthesis, and male pseudohermaphroditism resulting from deficient fetal testicular testosterone synthesis. Affected individuals are phenotypic females irrespective of gonadal sex, and frequently die in infancy if mineralocorticoid and glucocorticoid replacement are not instituted.
  • 序列相似性Contains 1 START domain.
  • 细胞定位Mitochondrion.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Cholesterol trafficker antibody
    • Luteinizing hormone induced protein antibody
    • mitochondrial antibody
    • Mitochondrial steroid acute regulatory protein antibody
    • StAR antibody
    • StAR related lipid transfer (START) domain containing 1 antibody
    • STAR_HUMAN antibody
    • StARD1 antibody
    • START domain containing 1 antibody
    • START domain containing protein 1 antibody
    • START domain-containing protein 1 antibody
    • Steroid acute regulatory protein antibody
    • Steroidogenic acute regulator antibody
    • Steroidogenic acute regulatory protein antibody
    • Steroidogenic acute regulatory protein mitochondrial antibody
    see all

Anti-StAR antibody 图像

  • Anti-StAR antibody (ab96637) at 1/1000 dilution + MOLT4 whole cell lysate at 30 µg

    Predicted band size : 32 kDa
  • All lanes : Anti-StAR antibody (ab96637) at 1/1000 dilution

    Lane 1 : Whole tissue lysate prepared from murine adrenal gland
    Lane 2 : Whole tissue lysate prepared from rat adrenal gland

    Lysates/proteins at 50 µg per lane.

    Secondary
    HRP conjugated goat anti-rabbit polyclonal at 1/2500 dilution
    Developed using the ECL technique

    Predicted band size : 32 kDa


    Exposure time : 20 seconds

    Image courtesy of an anonymous Abreview.

    See Abreview

Anti-StAR antibody (ab96637)参考文献

This product has been referenced in:
  • Barbero-Camps E  et al. Endoplasmic reticulum stress mediates amyloid ß neurotoxicity via mitochondrial cholesterol trafficking. Am J Pathol 184:2066-81 (2014). Mouse . Read more (PubMed: 24815354) »
  • Chen C  et al. Estradiol modulates translocator protein (TSPO) and steroid acute regulatory protein (StAR) via protein kinase A (PKA) signaling in hypothalamic astrocytes. Endocrinology 155:2976-85 (2014). WB ; Rat . Read more (PubMed: 24877623) »

See all 2 Publications for this product

Product Wall

Thank you very much for your interest in ab96637. Sinceab96637 has not been tested in pig, I can offer a discount off a future purchase if you buy ab96637 now, test it in pig, and submit feedback to us in the form of an Abreview. It doesn’t matte...

Read More

Thank you for submitting your completed questionnaire. To our knowledge ab96637 has not been previously tested in IHC-P. Thus is may be that this antibody does not function effectively in this application. However, results may be improved by doing an ...

Read More
Abcam guarantees this product to work in the species/application used in this Abreview.
Application Western blot
Sample Rat Tissue lysate - whole (Adrenal)
Loading amount 50 µg
Specification Adrenal
Gel Running Conditions Reduced Denaturing (12%)
Blocking step BSA as blocking agent for 2 hour(s) and 0 minute(s) · Concentration: 2% · Temperature: 22°C
Username

Abcam user community

Verified customer

提交于 Aug 23 2011

Abcam guarantees this product to work in the species/application used in this Abreview.
Application Western blot
Sample Mouse Tissue lysate - whole (Liver)
Loading amount 50 µg
Specification Liver
Gel Running Conditions Reduced Denaturing (12%)
Blocking step Milk as blocking agent for 2 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 22°C
Username

Abcam user community

Verified customer

提交于 Oct 20 2010

Abcam guarantees this product to work in the species/application used in this Abreview.
Application Western blot
Sample Human Cell lysate - whole cell (THP-1)
Loading amount 25 µg
Specification THP-1
Gel Running Conditions Reduced Denaturing (12%)
Blocking step Milk as blocking agent for 2 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 22°C
Username

Abcam user community

Verified customer

提交于 Sep 29 2010

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"