概述

  • 产品名称Anti-STAM1抗体
    参阅全部 STAM1 一抗
  • 描述
    兔多克隆抗体to STAM1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow, Zebrafish
  • 免疫原

    Recombinant protein fragment corresponding to a region within amino acids 16 and 296 of Human STAM1 (NP_003464).

  • 阳性对照
    • 293T, A431, H1299, HeLaS3, HepG2, MOLT4 or Raji cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab97856 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 65 kDa.

靶标

  • 功能Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.
  • 组织特异性Ubiquitously expressed.
  • 序列相似性Belongs to the STAM family.
    Contains 1 ITAM domain.
    Contains 1 SH3 domain.
    Contains 1 UIM (ubiquitin-interacting motif) repeat.
    Contains 1 VHS domain.
  • 翻译后修饰Phosphorylated on Tyr-198. Phosphorylated in response to IL2, IL3, IL4, IL7, CSF2/GM-CSF, EGF and PDGFB. Phosphorylated by activated PDGFRB.
  • 细胞定位Cytoplasm. Early endosome membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • HSE1 homolog antibody
    • Signal transducing adapter molecule 1 antibody
    • signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 antibody
    • STAM antibody
    • STAM-1 antibody
    • STAM1_HUMAN antibody
    see all

Anti-STAM1 antibody 图像

  • Anti-STAM1 antibody (ab97856) at 1/3000 dilution + H1299 whole cell lysate at 30 µg

    Predicted band size : 65 kDa

Anti-STAM1 antibody (ab97856)参考文献

ab97856 has not yet been referenced specifically in any publications.

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