概述

  • 产品名称Anti-STAM1抗体
    参阅全部 STAM1 一抗
  • 描述
    兔多克隆抗体to STAM1
  • 经测试应用适用于: IPmore details
    不适用于: WB
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rabbit, Guinea pig, Cow, Dog, Chimpanzee, Ferret, Rhesus monkey, Gorilla, Chinese Hamster, Orangutan
  • 免疫原

    Synthetic peptide, corresponding to a region within amino acids 400-450 of Human STAM1 (NP_003464.1).

  • 阳性对照
    • HeLa whole cell lysate.

性能

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应用

Our Abpromise guarantee covers the use of ab117817 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IP Use at 2-10 µg/mg of lysate.
  • 应用说明Is unsuitable for WB.
  • 靶标

    • 功能Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.
    • 组织特异性Ubiquitously expressed.
    • 序列相似性Belongs to the STAM family.
      Contains 1 ITAM domain.
      Contains 1 SH3 domain.
      Contains 1 UIM (ubiquitin-interacting motif) repeat.
      Contains 1 VHS domain.
    • 翻译后修饰Phosphorylated on Tyr-198. Phosphorylated in response to IL2, IL3, IL4, IL7, CSF2/GM-CSF, EGF and PDGFB. Phosphorylated by activated PDGFRB.
    • 细胞定位Cytoplasm. Early endosome membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • HSE1 homolog antibody
      • Signal transducing adapter molecule 1 antibody
      • signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 antibody
      • STAM antibody
      • STAM-1 antibody
      • STAM1_HUMAN antibody
      see all

    Anti-STAM1 antibody 图像

    • Detection of Human STAM1 in Immunoprecipitates of Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells using ab117817 at 6 µg/mg of lysate. Subsequent WB detection was done using an other anti Human STAM1 antibody.
      Detection: Chemiluminescence with an exposure time of 10 seconds.

    Anti-STAM1 antibody (ab117817)参考文献

    ab117817 has not yet been referenced specifically in any publications.

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