概述

  • 产品名称Anti-SS18抗体
    参阅全部 SS18 一抗
  • 描述
    兔多克隆抗体to SS18
  • 特异性ab66013 detects endogenous levels of total SS18 protein.
  • 经测试应用适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Synthetic peptide derived from N terminus of human SS18.

  • 阳性对照
    • Extracts from HepG2 cells, COLO205 cells and Jurkat cells.

性能

应用

Our Abpromise guarantee covers the use of ab66013 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/5000.
WB 1/500 - 1/1000. Detects a band of approximately 44 kDa (predicted molecular weight: 42 kDa).

靶标

  • 功能Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation.
  • 组织特异性Fairly ubiquitously expressed. Expressed in synovial sarcomas and in other human cell lines. The fusion genes SSXT-SSX1 and SSXT-SSX2 are expressed only in synovial sarcomas.
  • 疾病相关Note=A chromosomal aberration involving SS18 may be a cause of synovial sarcoma. Translocation t(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position of the breakpoint can occur (low frequency).
  • 序列相似性Belongs to the SS18 family.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • MGC116875 antibody
    • Protein SSXT antibody
    • Protein SYT antibody
    • SS18 antibody
    • SSXT antibody
    • SSXT/SSX4v fusion antibody
    • SSXT_HUMAN antibody
    • Synovial sarcoma translocated to X chromosome antibody
    • Synovial sarcoma translocated to X chromosome protein antibody
    • Synovial sarcoma translocation chromosome 18 antibody
    • SYT antibody
    • SYT SSX1 antibody
    • SYT SSX2 antibody
    • SYT/SSX4v fusion protein antibody
    • SYTSSX1 antibody
    • SYTSSX2 antibody
    see all

Anti-SS18 antibody 图像

  • All lanes : Anti-SS18 antibody (ab66013) at 1/500 dilution

    Lane 1 : HepG2 cell extracts
    Lane 2 : COLO205 cell extracts
    Lane 3 : Jurkat cell extracts
    Lane 4 : Jurkat cell extracts with immunising peptide at 10 µg

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 42 kDa
    Observed band size : 44 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 120 kDa,30 kDa,80 kDa. We are unsure as to the identity of these extra bands.

Anti-SS18 antibody (ab66013)参考文献

ab66013 has not yet been referenced specifically in any publications.

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