概述

  • 产品名称Anti-SRRM2抗体
    参阅全部 SRRM2 一抗
  • 描述
    兔多克隆抗体to SRRM2
  • 经测试应用适用于: IHC-P, ICC/IFmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant Protein Epitope Signature Tag antigen, corresponding to amino acids 1098 - 1203 of Human SRRM2 Isoforms 1 and 2 (Q9UQ35). Note: this sequence is missing in Isoform 3.

  • 阳性对照
    • Human liver tissue
      Human cell line U-2 OS

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液pH: 7.20
    Preservative: 0.02% Sodium azide
    Constituents: 59% PBS, 40% Glycerol
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

相关产品

应用

Our Abpromise guarantee covers the use of ab122719 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/500 - 1/1000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC/IF Use a concentration of 1 - 4 µg/ml.

Fixation/Permeabilization: PFA/Triton X-100

靶标

  • 功能Involved in pre-mRNA splicing. May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome. May do so by stabilizing the catalytic center or the position of the RNA substrate (By similarity). Binds to RNA.
  • 组织特异性Expressed in liver, placenta, and white blood cells.
  • 序列相似性Belongs to the CWC21 family.
  • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 细胞定位Nucleus speckle.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 300 kDa nuclear matrix antigen antibody
    • CWC21 antibody
    • KIAA0324 antibody
    • Ser/Arg-related nuclear matrix protein of 300 kDa antibody
    • Serine/arginine repetitive matrix protein 2 antibody
    • Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa antibody
    • Splicing coactivator subunit SRm300 antibody
    • SR-related nuclear matrix protein of 300 kDa antibody
    • SRL300 antibody
    • SRM300 antibody
    • SRRM2 antibody
    • SRRM2_HUMAN antibody
    • Tax-responsive enhancer element-binding protein 803 antibody
    • TaxREB803 antibody
    see all

Anti-SRRM2 antibody 图像

  • ab122719, at a 1/500 dilution, staining SRRM2 in paraffin-embedded Human liver tissue by Immunohistochemistry.
  • ab122719, at 4 ug/ml, staining SRRM2 in Human cell line U-2 OS by Immunoflouroscence.

Anti-SRRM2 antibody (ab122719)参考文献

This product has been referenced in:
  • Bai B  et al. U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer's disease. Proc Natl Acad Sci U S A 110:16562-7 (2013). IHC-FrFl ; Human . Read more (PubMed: 24023061) »

See 1 Publication for this product

Product Wall

There are currently no Abreviews or Questions for ab122719.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"