概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列QVQCQQSPVLAG
    • 氨基酸2 to 13

相关产品

技术指标

Our Abpromise guarantee covers the use of ab45681 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-SRD5A2 antibody (ab27469)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

常规信息

  • 别名
    • 3 oxo 5 alpha steroid 4 dehydrogenase 2
    • 3-oxo-5-alpha-steroid 4-dehydrogenase 2
    • 5 alpha SR2
    • 5 alpha-SR2
    • 5ART2
    • e II 5 alpha reductase
    • EC
    • MGC138457
    • Micropenis, included
    • S5A2_HUMAN
    • S5AR 2
    • SR type 2
    • SRD5A2
    • Steroid 5 alpha reductase 2
    • Steroid 5-alpha-reductase 2
    • Steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
    • Type II 5-alpha reductase
    see all
  • 功能Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
  • 组织特异性Expressed in high levels in the prostate and many other androgen-sensitive tissues.
  • 疾病相关Defects in SRD5A2 are the cause of pseudovaginal perineoscrotal hypospadias (PPSH) [MIM:264600]. A form of male pseudohermaphroditism in which 46,XY males show ambiguous genitalia at birth, including perineal hypospadias and a blind perineal pouch, and develop masculinization at puberty. The name of the disorder stems from the finding of a blind-ending perineal opening resembling a vagina and a severely hypospadiac penis with the urethra opening onto the perineum.
  • 序列相似性Belongs to the steroid 5-alpha reductase family.
  • 细胞定位Microsome membrane. Endoplasmic reticulum membrane.
  • Information by UniProt

SRD5A2 peptide (2-13) (ab45681)参考文献

ab45681 has not yet been referenced specifically in any publications.

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