概述

  • 产品名称Anti-SRD5A2抗体
    参阅全部 SRD5A2 一抗
  • 描述
    兔多克隆抗体to SRD5A2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Rabbit, Pig
  • 免疫原

    Synthetic peptide corresponding to a region within N-terminal amino acids 1-50 of human SRD5A2 (NP_000339).

  • 阳性对照
    • THP-1 cell lysate

性能

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应用

Our Abpromise guarantee covers the use of ab99065 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 28 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
  • 组织特异性Expressed in high levels in the prostate and many other androgen-sensitive tissues.
  • 疾病相关Defects in SRD5A2 are the cause of pseudovaginal perineoscrotal hypospadias (PPSH) [MIM:264600]. A form of male pseudohermaphroditism in which 46,XY males show ambiguous genitalia at birth, including perineal hypospadias and a blind perineal pouch, and develop masculinization at puberty. The name of the disorder stems from the finding of a blind-ending perineal opening resembling a vagina and a severely hypospadiac penis with the urethra opening onto the perineum.
  • 序列相似性Belongs to the steroid 5-alpha reductase family.
  • 细胞定位Microsome membrane. Endoplasmic reticulum membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 3 oxo 5 alpha steroid 4 dehydrogenase 2 antibody
    • 3-oxo-5-alpha-steroid 4-dehydrogenase 2 antibody
    • 5 alpha SR2 antibody
    • 5 alpha-SR2 antibody
    • 5ART2 antibody
    • e II 5 alpha reductase antibody
    • EC antibody
    • MGC138457 antibody
    • Micropenis, included antibody
    • S5A2_HUMAN antibody
    • S5AR 2 antibody
    • SR type 2 antibody
    • SRD5A2 antibody
    • Steroid 5 alpha reductase 2 antibody
    • Steroid 5-alpha-reductase 2 antibody
    • Steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) antibody
    • Type II 5-alpha reductase antibody
    see all

Anti-SRD5A2 antibody 图像

  • Anti-SRD5A2 antibody (ab99065) at 1 µg/ml + THP-1 cell lysate at 10 µg

    Predicted band size : 28 kDa

Anti-SRD5A2 antibody (ab99065)参考文献

ab99065 has not yet been referenced specifically in any publications.

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