概述

描述

  • 性质Synthetic

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技术指标

Our Abpromise guarantee covers the use of ab4915 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking

  • 形式Liquid
  • 补充说明


    This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and AIB 1, catalog ab2831. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~ 70-fold) for competitive inhibition of antibody-protein binding reactions.

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

常规信息

  • 别名
    • ACTR
    • AIB 1
    • AIB-1
    • AIB1
    • Amplified in breast cancer 1
    • Amplified in breast cancer 1 protein
    • bHLHe42
    • CAGH 16
    • CAGH16
    • CBP interacting protein
    • CBP-interacting protein
    • Class E basic helix-loop-helix protein 42
    • CTG 26
    • CTG26
    • KAT13B / AIB1
    • MGC141848
    • NCOA 3
    • NCoA-3
    • Ncoa3
    • NCOA3_HUMAN
    • Nuclear receptor coactivator 3
    • pCIP
    • RAC 3
    • RAC-3
    • RAC3
    • Receptor associated coactivator 3
    • Receptor-associated coactivator 3
    • SRC 3
    • SRC-3
    • SRC3
    • Steroid receptor coactivator protein 3
    • Thyroid hormone receptor activator molecule 1
    • TNRC14
    • TNRC16
    • TRAM 1
    • TRAM-1
    • TRAM1
    see all
  • 功能Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. Interacts with PSMB9.
  • 组织特异性Widely expressed. High expression in heart, skeletal muscle, pancreas and placenta. Low expression in brain, and very low in lung, liver and kidney.
  • 序列相似性Belongs to the SRC/p160 nuclear receptor coactivator family.
    Contains 1 basic helix-loop-helix (bHLH) domain.
    Contains 1 PAS (PER-ARNT-SIM) domain.
  • 结构域Contains three Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. Motifs 1 and 2 are essential for the association with nuclear receptors, and constitute the RID domain (Receptor-interacting domain).
  • 翻译后修饰Acetylated by CREBBP. Acetylation occurs in the RID domain, and disrupts the interaction with nuclear receptors and regulates its function.
    Methylated by CARM1.
    Phosphorylated by IKK complex. Regulated its function.
  • 细胞定位Cytoplasm. Nucleus. Mainly cytoplasmic and weakly nuclear. Upon TNF activation and subsequent phosphorylation, it translocates from the cytoplasm to the nucleus.
  • Information by UniProt

SRC3 peptide (ab4915)参考文献

ab4915 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"