Anti-SRC3抗体(ab85452)

概述

• 产品名称Anti-SRC3抗体
  参阅全部 SRC3 一抗
• 描述
  兔多克隆抗体to SRC3
• 经测试应用适用于: IHC-P, WBmore details
• 种属反应性
  与反应: Human
  预测可用于: Rat, Horse, Cat, Dog, Pig
• 免疫原

  Synthetic peptide corresponding to a region within the internal sequence amino acids 576-625 (DQNPVESSMC QSNSRDHLSD KESKESSVEG AENQRGPLES KGHKKLLQLL) of human KAT13B/ AIB1 (NP_006525).

  Run BLAST with Run BLAST with
• 阳性对照
  • 293T cell lysate

性能

• 形式Liquid
• 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
• 存储溶液Preservative: None
  Constituents: 2% Sucrose, PBS
• Concentration information loading...
• 纯度Immunogen affinity purified
• 纯化说明ab85452 is purified by peptide affinity chromatography method.
• 克隆多克隆
• 同种型IgG
• 研究领域
  • Epigenetics and Nuclear Signaling
  • Chromatin Modifying Enzymes
  • Acetylation

  • Signal Transduction
  • Signaling Pathway
  • Nuclear Signaling
  • Nuclear Hormone Receptors
  • Co-activators/co-repressors

  • Epigenetics and Nuclear Signaling
  • Nuclear Signaling Pathways
  • Nuclear Receptors
  • Co-activators/co-repressors

  • Epigenetics and Nuclear Signaling
  • Chromatin Modifying Enzymes
  • Acetylation
  • HAT

  • Cancer
  • Signal transduction
  • Nuclear signaling
  • Nuclear hormone receptors
  • Coactivators and repressors

  • Cancer
  • Cancer Metabolism
  • Metabolic signaling pathway
  • Metabolism of lipids and lipoproteins

  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Lipid and lipoprotein metabolism
  • Lipid metabolism

  • Metabolism
  • Types of disease
  • Obesity

  • Metabolism
  • Types of disease
  • Cancer

相关产品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

应用

靶标

• 功能Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. Interacts with PSMB9.
• 组织特异性Widely expressed. High expression in heart, skeletal muscle, pancreas and placenta. Low expression in brain, and very low in lung, liver and kidney.
• 序列相似性Belongs to the SRC/p160 nuclear receptor coactivator family.
  Contains 1 basic helix-loop-helix (bHLH) domain.
  Contains 1 PAS (PER-ARNT-SIM) domain.
• 结构域Contains three Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. Motifs 1 and 2 are essential for the association with nuclear receptors, and constitute the RID domain (Receptor-interacting domain).
• 翻译后修饰Acetylated by CREBBP. Acetylation occurs in the RID domain, and disrupts the interaction with nuclear receptors and regulates its function.
  Methylated by CARM1.
  Phosphorylated by IKK complex. Regulated its function.
• 细胞定位Cytoplasm. Nucleus. Mainly cytoplasmic and weakly nuclear. Upon TNF activation and subsequent phosphorylation, it translocates from the cytoplasm to the nucleus.

• Target information above from: UniProt accession Q9Y6Q9 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 数据库链接
  • Entrez Gene: 8202 Human
  • Entrez Gene: 84584 Rat
  • Omim: 601937 Human
  • SwissProt: Q9Y6Q9 Human
  • SwissProt: Q9EPU2 Rat
  • Unigene: 592142 Human
  • Unigene: 20691 Rat
• 别名
  • ACTR antibody
  • AIB 1 antibody
  • AIB-1 antibody

  • AIB1 antibody
  • Amplified in breast cancer 1 antibody
  • Amplified in breast cancer 1 protein antibody
  • bHLHe42 antibody
  • CAGH 16 antibody
  • CAGH16 antibody
  • CBP interacting protein antibody
  • CBP-interacting protein antibody
  • Class E basic helix-loop-helix protein 42 antibody
  • CTG 26 antibody
  • CTG26 antibody
  • KAT13B / AIB1 antibody
  • MGC141848 antibody
  • NCOA 3 antibody
  • NCoA-3 antibody
  • Ncoa3 antibody
  • NCOA3_HUMAN antibody
  • Nuclear receptor coactivator 3 antibody
  • pCIP antibody
  • RAC 3 antibody
  • RAC-3 antibody
  • RAC3 antibody
  • Receptor associated coactivator 3 antibody
  • Receptor-associated coactivator 3 antibody
  • SRC 3 antibody
  • SRC-3 antibody
  • SRC3 antibody
  • Steroid receptor coactivator protein 3 antibody
  • Thyroid hormone receptor activator molecule 1 antibody
  • TNRC14 antibody
  • TNRC16 antibody
  • TRAM 1 antibody
  • TRAM-1 antibody
  • TRAM1 antibody

  see all