-
功能
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. Interacts with PSMB9.
-
组织特异性
Widely expressed. High expression in heart, skeletal muscle, pancreas and placenta. Low expression in brain, and very low in lung, liver and kidney.
-
序列相似性
Belongs to the SRC/p160 nuclear receptor coactivator family.
Contains 1 basic helix-loop-helix (bHLH) domain.
Contains 1 PAS (PER-ARNT-SIM) domain.
-
结构域
Contains three Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. Motifs 1 and 2 are essential for the association with nuclear receptors, and constitute the RID domain (Receptor-interacting domain).
-
翻译后修饰
Acetylated by CREBBP. Acetylation occurs in the RID domain, and disrupts the interaction with nuclear receptors and regulates its function.
Methylated by CARM1.
Phosphorylated by IKK complex. Regulated its function.
-
细胞定位
Cytoplasm. Nucleus. Mainly cytoplasmic and weakly nuclear. Upon TNF activation and subsequent phosphorylation, it translocates from the cytoplasm to the nucleus.
-
Information by UniProt
-
数据库链接
-
别名
- ACTR antibody
- AIB 1 antibody
- AIB-1 antibody
- AIB1 antibody
- Amplified in breast cancer 1 antibody
- Amplified in breast cancer 1 protein antibody
- bHLHe42 antibody
- CAGH 16 antibody
- CAGH16 antibody
- CBP interacting protein antibody
- CBP-interacting protein antibody
- Class E basic helix-loop-helix protein 42 antibody
- CTG 26 antibody
- CTG26 antibody
- KAT13B / AIB1 antibody
- MGC141848 antibody
- NCOA 3 antibody
- NCoA-3 antibody
- Ncoa3 antibody
- NCOA3_HUMAN antibody
- Nuclear receptor coactivator 3 antibody
- pCIP antibody
- RAC 3 antibody
- RAC-3 antibody
- RAC3 antibody
- Receptor associated coactivator 3 antibody
- Receptor-associated coactivator 3 antibody
- SRC 3 antibody
- SRC-3 antibody
- SRC3 antibody
- Steroid receptor coactivator protein 3 antibody
- Thyroid hormone receptor activator molecule 1 antibody
- TNRC14 antibody
- TNRC16 antibody
- TRAM 1 antibody
- TRAM-1 antibody
- TRAM1 antibody
see all