概述

  • 产品名称Anti-SRA1抗体
    参阅全部 SRA1 一抗
  • 描述
    兔多克隆抗体to SRA1
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Chimpanzee, Rhesus monkey, Gorilla
  • 免疫原

    Synthetic peptide corresponding to a region between residues 50 and 100 of human SRA1 (NP_001030312.1).

  • 阳性对照
    • Human metastatic lymph node and human breast carcinoma tissues.

性能

应用

Our Abpromise guarantee covers the use of ab84388 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
  • 应用说明IHC-P: 1/100 - 1/500.
    Epitope exposure with citrate buffer will enhance staining.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis.
    • 组织特异性Highly expressed in liver and skeletal muscle and to a lesser extent in brain. Also expressed in both normal and tumorigenic breast epithelial cell lines. Significantly up-regulated in human tumors of the breast, ovary, and uterus.
    • 序列相似性Belongs to the SRA1 family.
    • 细胞定位Nucleus. Cytoplasm.
    • Information by UniProt
    • 数据库链接
    • 别名
      • MGC87674 antibody
      • PP7684 antibody
      • SR A1 antibody
      • SRA antibody
      • SRA1 antibody
      • SRA1_HUMAN antibody
      • SRAP antibody
      • Steroid receptor coactivator antibody
      • Steroid receptor RNA activator 1 (complexes with NCOA1) antibody
      • Steroid receptor RNA activator 1 antibody
      • Steroid receptor RNA activator protein antibody
      • STRAA1 antibody
      see all

    Anti-SRA1 antibody 图像

    • ab84388, at a 1/100 dilution, staining SRA1 in formalin fixed, paraffin embedded human metastatic lymph node tissue by Immunohistochemistry.
      Detection: DAB staining.
    • ab84388, at a 1/100 dilution, staining SRA1 in formalin fixed, paraffin embedded human breast carcinoma tissue by Immunohistochemistry.
      Detection: DAB staining.

    Anti-SRA1 antibody (ab84388)参考文献

    This product has been referenced in:
    • Lee J  et al. The liver is populated by a broad spectrum of markers for macrophages. In alcoholic hepatitis the macrophages are M1 and M2. Exp Mol Pathol N/A:N/A (2013). IHC-P ; Human . Read more (PubMed: 24145004) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"