Anti-SR1抗体(ab71983)
Key features and details
- Rabbit polyclonal to SR1
- Suitable for: WB, IHC-P
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
概述
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产品名称
Anti-SR1抗体 -
描述
兔多克隆抗体to SR1 -
宿主
Rabbit -
经测试应用
适用于: WB, IHC-Pmore details -
种属反应性
与反应: Mouse, Rat, Human
预测可用于: Chicken -
免疫原
Synthetic peptide (Human) sequence is amino acids 50-100 in length from Sorcin. (NP_003121).
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.40
Preservative: 0.05% Sodium azide
Constituent: PBS -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab71983于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
Use a concentration of 0.5 - 2 µg/ml. Detects a band of approximately 22 kDa (predicted molecular weight: 22 kDa).
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IHC-P |
Use at an assay dependent concentration.
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说明 |
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WB
Use a concentration of 0.5 - 2 µg/ml. Detects a band of approximately 22 kDa (predicted molecular weight: 22 kDa). |
IHC-P
Use at an assay dependent concentration. |
靶标
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功能
Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels. -
组织特异性
Detected in cardiac myocytes. -
序列相似性
Contains 4 EF-hand domains. -
细胞定位
Cytoplasm. Sarcoplasmic reticulum membrane. Relocates to the sarcoplasmic reticulum membrane in response to elevated calcium levels. - Information by UniProt
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数据库链接
- Entrez Gene: 420538 Chicken
- Entrez Gene: 6717 Human
- Entrez Gene: 109552 Mouse
- Entrez Gene: 683667 Rat
- Omim: 182520 Human
- SwissProt: P30626 Human
- SwissProt: Q6P069 Mouse
- Unigene: 489040 Human
see all -
别名
- 22 kDa protein antibody
- Calcium binding protein amplified in mutlidrug resistant cells antibody
- CP 22 antibody
see all
图片
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Paraffin embedded human small intestine tissue immunostained using ab71983 at 10 µg/ml.
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All lanes : Anti-SR1 antibody (ab71983) at 1 µg/ml
Lane 1 : human brain lysate
Lane 2 : human brain lysate with immunising peptide
Lane 3 : mouse brain lysate
Lane 4 : rat brain lysate
Predicted band size: 22 kDa
Observed band size: 22 kDa
数据表及文件
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Datasheet download
文献 (5)
ab71983 被引用在 5 文献中.
- Dekel E et al. 20S proteasomes secreted by the malaria parasite promote its growth. Nat Commun 12:1172 (2021). PubMed: 33608523
- Zhang J et al. Clinical Significance and Prognostic Value of Human Soluble Resistance-Related Calcium-Binding Protein: A Pan-Cancer Analysis. Front Med (Lausanne) 8:752619 (2021). PubMed: 34869449
- Genovese I et al. Sorcin is an early marker of neurodegeneration, Ca2+ dysregulation and endoplasmic reticulum stress associated to neurodegenerative diseases. Cell Death Dis 11:861 (2020). PubMed: 33060591
- Ranum PT et al. Insights into the Biology of Hearing and Deafness Revealed by Single-Cell RNA Sequencing. Cell Rep 26:3160-3171.e3 (2019). PubMed: 30865901
- Wright MF et al. Mechanisms of intracellular calcium homeostasis in developing and mature bovine corpora lutea. Biol Reprod 90:55 (2014). WB, ICC/IF ; Cow . PubMed: 24501170