SQ 22536,Non-competitive adenylyl cyclase抑制剂(ab120642)
Key features and details
- Non-competitive adenylyl cyclase inhibitor
- CAS Number: 17318-31-9
- Purity: > 99%
- Soluble in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
SQ 22536,Non-competitive adenylyl cyclase抑制剂 -
描述
Non-competitive adenylyl cyclase抑制剂 -
生物学描述
Non-competitive adenylyl cyclase inhibitor. Inhibits catecholamine stimulated cAMP production (IC50 values are 0.08-1.45 and 0.08-0.27 mM in catfish and rat hepatocyte cell membranes, respectively). Inhibits muscarinic Ca2+ signalling in rat carotid bodies in vitro.
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纯度
> 99% -
常规说明
This compound appears to be unstable in strongly acidic solutions. We therefore recommend avoiding exposure to low pH.
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CAS编号
17318-31-9 -
化学结构
性能
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化学名称
9-(Tetrahydro-2-furanyl)-9H-purin-6-amine -
分子量
205.22 -
分子式
C9H11N5O -
PubChem识别号
5270 -
存放说明
Store at +4°C. Please see notes section. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 50 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1CC(OC1)N2C=NC3=C(N=CN=C32)N -
来源
Synthetic
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研究领域
- Biochemicals
- Pharmacology
- Signaling
- Signal transduction
- Inositol & cAMP signaling
- Adenylyl cyclase
- Activators
- Biochemicals
- Research Area
- Heart disease
- Signaling
- Inositol & cAMP signaling
- Adenylyl cyclase
- Activators
- Biochemicals
- Research Area
- Pain & inflammation
- Signaling
- Inositol & cAMP signaling
- Adenylyl cyclase
- Activators
- Biochemicals
- Research Area
- Alzheimer's Disease
- Signaling
- Signal transduction
- Inositol & cAMP signaling
- Adenylyl cyclase
- Activators
- Biochemicals
- Research Area
- Diabetes
- Signaling
- Signal transduction
- Inositol & cAMP signaling
- Adenylyl cyclase
- Activators
- Biochemicals
- Research Area
- Hypertension
- Signaling
- Signal transduction
- Inositol & cAMP signaling
- Adenylyl cyclase
- Activators
- Biochemicals
- Research Area
- Obesity
- Signaling
- Signal transduction
- Inositol & cAMP signaling
- Adenylyl cyclase
- Activators
- Biochemicals
- Research Area
- Respiratory disease
- Signaling
- Inositol & cAMP signaling
- Adenylyl cyclase
- Activators
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (5)
ab120642 被引用在 5 文献中.
- Kulebyakin K et al. Dynamic Balance between PTH1R-Dependent Signal Cascades Determines Its Pro- or Anti-Osteogenic Effects on MSC. Cells 11:N/A (2022). PubMed: 36359914
- Pal S et al. Skeletal restoration by phosphodiesterase 5 inhibitors in osteopenic mice: Evidence of osteoanabolic and osteoangiogenic effects of the drugs. Bone 135:115305 (2020). PubMed: 32126313
- Weber L et al. Characterization of the Olfactory Receptor OR10H1 in Human Urinary Bladder Cancer. Front Physiol 9:456 (2018). PubMed: 29867524
- Tyurin-Kuzmin PA et al. Activation of ß-adrenergic receptors is required for elevated a1A-adrenoreceptors expression and signaling in mesenchymal stromal cells. Sci Rep 6:32835 (2016). PubMed: 27596381
- Ohira H et al. Butyrate attenuates lipolysis in adipocytes co-cultured with macrophages through non-prostaglandin E2-mediated and prostaglandin E2-mediated pathways. Lipids Health Dis 15:213 (2016). PubMed: 27938411