概述

  • 产品名称Anti-SPTLC1抗体
    参阅全部 SPTLC1 一抗
  • 描述
    兔多克隆抗体to SPTLC1
  • 特异性At least two isoforms of SPTLC1 are known to exist; this antibody will detect only isoform a. SPTLC1 antibody is predicted to not cross-react with SPTLC2.
  • 经测试应用适用于: WB, ICCmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    A 17 amino acid peptide near the carboxy terminus of Human SPTLC (NP_6406).

  • 阳性对照
    • Human Lung tissue lysate.

性能

应用

Our Abpromise guarantee covers the use of ab112569 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 53 kDa.
ICC Use a concentration of 5 µg/ml.

靶标

  • 功能Serine palmitoyltransferase (SPT). The heterodimer formed with LCB2 (SPTLC2 or SPTLC3) constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SSSPTA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SSSPTA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SSSPTB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SSSPTB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference.
  • 组织特异性Widely expressed. Not detected in small intestine.
  • 通路Lipid metabolism; sphingolipid metabolism.
  • 疾病相关Defects in SPTLC1 are the cause of hereditary sensory and autonomic neuropathy type 1A (HSAN1A) [MIM:162400]. The hereditary sensory and autonomic neuropathies are a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN1A is an autosomal dominant axonal neuropathy with onset in the second or third decades. Initial symptoms are loss of pain, touch, heat, and cold sensation over the feet, followed by distal muscle wasting and weakness. Loss of pain sensation leads to chronic skin ulcers and distal amputations.
  • 序列相似性Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
  • 细胞定位Endoplasmic reticulum membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • HSAN antibody
    • HSAN1 antibody
    • HSN1 antibody
    • LBC1 antibody
    • LCB 1 antibody
    • LCB1 antibody
    • Long chain base biosynthesis protein 1 antibody
    • MGC14645 antibody
    • Serine C palmitoyltransferase antibody
    • Serine palmitoyl CoA transferase 1 antibody
    • Serine palmitoyltransferase 1 antibody
    • Serine palmitoyltransferase long chain base subunit 1 antibody
    • Serine palmitoyltransferase subunit 1 antibody
    • Serine-palmitoyl-CoA transferase 1 antibody
    • SPT 1 antibody
    • SPT1 antibody
    • SPTC1_HUMAN antibody
    • SPTI antibody
    • SPTLC 1 antibody
    • SPTLC1 antibody
    see all

Anti-SPTLC1 antibody 图像

  • All lanes : Anti-SPTLC1 antibody (ab112569) at 1 µg/ml

    Lane 1 : Human lung tissue lysate
    Lane 2 : Human lung tissue lysate with blocking peptide

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 53 kDa
  • Immunohistochemistry of SPTLC1 in human lung tissue with ab112569 at 5 ug/mL.

Anti-SPTLC1 antibody (ab112569)参考文献

ab112569 has not yet been referenced specifically in any publications.

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