概述

  • 产品名称Anti-SPR抗体
    参阅全部 SPR 一抗
  • 描述
    兔多克隆抗体to SPR
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant protein fragment contain a sequence corresponding to a region within amino acids 65 and 253 of Human SPR (Uniprot ID: P35270).

  • 阳性对照
    • 293T, H1299, HeLa, HepG2 and A431 cell lysates

性能

应用

Our Abpromise guarantee covers the use of ab96027 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 28 kDa.

靶标

  • 功能Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin.
  • 疾病相关Defects in SPR are the cause of dystonia DOPA-responsive due to sepiapterin reductase deficiency (DRDSPRD) [MIM:612716]. In the majority of cases, patients manifest progressive psychomotor retardation, dystonia and spasticity. Cognitive anomalies are also often present. The disease is due to severe dopamine and serotonin deficiencies in the central nervous system caused by a defect in BH4 synthesis. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures.
  • 序列相似性Belongs to the sepiapterin reductase family.
  • 翻译后修饰In vitro phosphorylation of Ser-213 by CaMK2 does not change kinetic parameters.
  • 细胞定位Cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • OTTHUMP00000160199 antibody
    • SDR38C1 antibody
    • Sepiapterin reductase (7,8 dihydrobiopterin:NADP+ oxidoreductase) antibody
    • Sepiapterin reductase antibody
    • Short chain dehydrogenase/reductase family 38C, member 1 antibody
    • SPR antibody
    • SPRE_HUMAN antibody
    see all

Anti-SPR antibody 图像

  • Anti-SPR antibody (ab96027) at 1/1000 dilution + A431 whole cell lysate at 30 µg

    Predicted band size : 28 kDa

Anti-SPR antibody (ab96027)参考文献

ab96027 has not yet been referenced specifically in any publications.

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