概述

  • 产品名称Anti-SPR抗体
    参阅全部 SPR 一抗
  • 描述
    兔多克隆抗体to SPR
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Synthetic peptide conjugated to KLH, between C terminal amino acids 232-261 of Human SPR.

  • 阳性对照
    • Mouse liver tissue

性能

应用

Our Abpromise guarantee covers the use of ab103353 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/1000. Predicted molecular weight: 28 kDa.

靶标

  • 功能Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin.
  • 疾病相关Defects in SPR are the cause of dystonia DOPA-responsive due to sepiapterin reductase deficiency (DRDSPRD) [MIM:612716]. In the majority of cases, patients manifest progressive psychomotor retardation, dystonia and spasticity. Cognitive anomalies are also often present. The disease is due to severe dopamine and serotonin deficiencies in the central nervous system caused by a defect in BH4 synthesis. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures.
  • 序列相似性Belongs to the sepiapterin reductase family.
  • 翻译后修饰In vitro phosphorylation of Ser-213 by CaMK2 does not change kinetic parameters.
  • 细胞定位Cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • OTTHUMP00000160199 antibody
    • SDR38C1 antibody
    • Sepiapterin reductase (7,8 dihydrobiopterin:NADP+ oxidoreductase) antibody
    • Sepiapterin reductase antibody
    • Short chain dehydrogenase/reductase family 38C, member 1 antibody
    • SPR antibody
    • SPRE_HUMAN antibody
    see all

Anti-SPR antibody 图像

  • Anti-SPR antibody (ab103353) at 1/1000 dilution + Mouse liver tissue lysate at 35 µg

    Secondary
    Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution

    Predicted band size : 28 kDa

    Blocking/Dilution buffer: 5% NFDM/TBST.

Anti-SPR antibody (ab103353)参考文献

ab103353 has not yet been referenced specifically in any publications.

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