概述

  • 产品名称Spiperone hydrochloride
  • 描述
    5-HT and D2-like receptor antagonist
  • 生物学描述5-HT and D2-like receptor antagonist. (IC50 values are 1.6 and 15 nM at 5-HT2 and 5-HT1C receptors, respectively. Ki values are 0.06 ( D2), 0.6 (D3), 0.08 (D4), ~ 350 (D1) and ~ 3500 nM (D5)). Potently enhances intracellular Ca2+ levels. Additionally activates Ca2+-activated Cl- channels (CaCC) to induce Cl- secretion.
  • 纯度> 98%

性能

    Spiperone hydrochloride (ab120549)参考文献

    This product has been referenced in:
    • Liang L  et al. Spiperone, identified through compound screening, activates calcium-dependent chloride secretion in the airway. Am J Physiol Cell Physiol 296:C131-41 (2009). Read more (PubMed: 18987251) »
    • Lu D & Carson DA Spiperone enhances intracellular calcium level and inhibits the Wnt signaling pathway. BMC Pharmacol 9:13 (2009). Read more (PubMed: 19948059) »
    • Woodward RM  et al. Actions of dopamine and dopaminergic drugs on cloned serotonin receptors expressed in Xenopus oocytes. Proc Natl Acad Sci U S A 89:4708-12 (1992). Read more (PubMed: 1350095) »

    See 1 Publication for this product

    Product Wall

    There are currently no Abreviews or Questions for ab120549.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"