概述

  • 产品名称Anti-SPINK5抗体
    参阅全部 SPINK5 一抗
  • 描述
    兔多克隆抗体to SPINK5
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    A KLH conjugated synthetic peptide selected from the N terminal region of Human SPINK5.

  • 阳性对照
    • A2058 cell line lysate

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • 存储溶液Preservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明This antibody is purified through a protein A column, followed by peptide affinity purification.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab92582 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
ELISA
  • 应用说明ELISA: 1/1000.
    WB: 1/100 - 1/500. Predicted molecular weight: 121 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense-activating and desquamation-involved proteases. Inhibits KLK5, it's major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin.
    • 组织特异性Highly expressed in the thymus and stratum corneum. Also found in the oral mucosa, parathyroid gland, Bartholin's glands, tonsils, and vaginal epithelium. Very low levels are detected in lung, kidney, and prostate.
    • 疾病相关Defects in SPINK5 are the cause of Netherton syndrome (NETH) [MIM:256500]. NETH is an autosomal recessive congenital ichthyosis associated with hair shaft abnormalities and anomalies of the immune system. Typical features are ichthyosis linearis circumflexa, ichthyosiform erythroderma, trichorrhexis invaginata (bamboo hair), atopic dermatitis, and hayfever. High postnatal mortality is due to failure to thrive, infections and hypernatremic dehydration.
    • 序列相似性Contains 15 Kazal-like domains.
    • 结构域Contains at least one active inhibitory domain for trypsin (domain 6).
    • 翻译后修饰Proteolytically processed by furin in individual domains (D1, D5, D6, D8 through D11, and D9 through D15) exhibiting various inhibitory potentials for multiple proteases.
    • 细胞定位Secreted.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Hemofiltrate peptide HF7665 antibody
      • ISK5_HUMAN antibody
      • LEKTI antibody
      • Lympho-epithelial Kazal-type-related inhibitor antibody
      • Lymphoepithelial Kazal type related inhibitor antibody
      • NETS antibody
      • NS antibody
      • Serine peptidase inhibitor Kazal type 5 antibody
      • SPINK5 antibody
      • VAKTI antibody
      see all

    Anti-SPINK5 antibody 图像

    • Anti-SPINK5 antibody (ab92582) at 1/100 dilution + A2058 cell line lysate at 35 µg

      Predicted band size : 121 kDa

    Anti-SPINK5 antibody (ab92582)参考文献

    ab92582 has not yet been referenced specifically in any publications.

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