Anti-Spi2A抗体[MoFo29.2] (ab28358)

概述

  • 产品名称Anti-Spi2A抗体[MoFo29.2]
    参阅全部 Spi2A 一抗
  • 描述
    亚美尼亚仓鼠单克隆抗体[MoFo29.2] to Spi2A
  • 特异性ab28358 recognises mouse Serine Protease Inhibitor 2A (Spi2A).
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse
  • 免疫原

    Synthetic peptide corresponding to Mouse Spi2A aa 406-426 (C terminal).
    Sequence:

    NPERSTNFPNGEGASSQRC

  • 表位ab28358 reacts with an epitope located in the region encoded by amino acids 406 - 426 including the C terminus of Spi2A.

性能

应用

Our Abpromise guarantee covers the use of ab28358 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000. Predicted molecular weight: 49 kDa.

靶标

  • 功能Serine and cysteine protease inhibitor. Can inhibit lysosomal papain-like proteases including the cathepsins B, G, H, K, L and V. Ineffective against elastase, granzyme A, granzyme B, or caspases 3, 8 or 9. Inhibition of cytoplasmic cathepsin B following release from the lysosome may protect cells from apoptosis. This may facilitate the survival of progenitor T-cells and the subsequent development of long term memory CD8 T-cells.
  • 组织特异性Expressed in bone marrow (particularly hematopoietic stem cells), heart, kidney, liver, lung, skeletal muscle, spleen, testis, thymus and T-cells.
  • 序列相似性Belongs to the serpin family.
  • 发展阶段T-cell specific expression rises during the differentiation of CD8 T-cell progenitors into memory CD8 T-cells.
  • 结构域The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the serpin reactive site and the protease. The resulting inactive serpin-protease complex is highly stable (By similarity). Variability within the reactive center loop (RCL) sequences of Serpina3 paralogs may determine target protease specificity.
  • 细胞定位Cytoplasm. Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Serine protease inhibitor 2A antibody
    • Serine protease inhibitor A3G antibody
    • Serpin 2A antibody
    • Serpin A3G antibody
    • Serpina3g antibody
    • SPA3G_MOUSE antibody
    see all

Anti-Spi2A antibody [MoFo29.2] 图像

  • All lanes : Anti-Spi2A antibody [MoFo29.2] (ab28358)

    Lane 1 : NIH 3T3 transfected cells with Bcl3
    Lane 2 : NIH 3T3 transfected cells with Spi2A


    Predicted band size : 49 kDa

Anti-Spi2A antibody [MoFo29.2] (ab28358)参考文献

ab28358 has not yet been referenced specifically in any publications.

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