Anti-Sphingomyelin Synthase 2抗体(ab103060)

概述

  • 产品名称Anti-Sphingomyelin Synthase 2抗体
    参阅全部 Sphingomyelin Synthase 2 一抗
  • 描述
    兔多克隆抗体to Sphingomyelin Synthase 2
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, between C-terminal amino acids 336-365 of Human Sphingomyelin Synthase 2.

  • 阳性对照
    • CEM cell line, Human Brain Tissue

性能

应用

Our Abpromise guarantee covers the use of ab103060 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 42 kDa.
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能Bidirectional lipid cholinephosphotransferase capable of converting phosphatidylcholine (PC) and ceramide to sphingomyelin (SM) and diacylglycerol (DAG) and vice versa. Direction is dependent on the relative concentrations of DAG and ceramide as phosphocholine acceptors. Directly and specifically recognizes the choline head group on the substrate. Also requires two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Does not function strictly as a SM synthase. Required for cell growth.
  • 组织特异性Brain, heart, kidney, liver, muscle and stomach.
  • 序列相似性Belongs to the sphingomyelin synthase family.
  • 翻译后修饰Palmitoylated on Cys-331, Cys-332, Cys-343 and Cys-348; which plays an important role in plasma membrane localization.
  • 细胞定位Cell membrane. Golgi apparatus membrane. Predominantly plasma membrane, some in Golgi apparatus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • MGC26963 antibody
    • Phosphatidylcholine:ceramide cholinephosphotransferase 2 antibody
    • SGMS 2 antibody
    • Sgms2 antibody
    • SM synthase antibody
    • SMS 2 antibody
    • SMS2 antibody
    • SMS2_HUMAN antibody
    • Sphingomyelin synthase 2 antibody
    see all

Anti-Sphingomyelin Synthase 2 antibody 图像

  • Anti-Sphingomyelin Synthase 2 antibody (ab103060) at 1/100 dilution + CEM cell lysate at 35 µg

    Predicted band size : 42 kDa
  • IHC analysis in formalin fixed and paraffin embedded Human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining, using ab103060 at a dilution of 1/50.

Anti-Sphingomyelin Synthase 2 antibody (ab103060)参考文献

ab103060 has not yet been referenced specifically in any publications.

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