概述

  • 产品名称SPEN肽(1503-1517)

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列C-DSEGKMDDKKEDHKE
    • 氨基酸1503 to 1517

技术指标

Our Abpromise guarantee covers the use of ab45877 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

常规信息

  • 别名
    • MINT
    • Nuclear receptor transcription cofactor
    • RBM15C
    • SHARP
    • SPEN homolog
    • Spen homolog transcriptional regulator
    see all
  • 相关性SPEN is an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. It is a negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. SPEN blocks the differentiation of precursor B-cells into marginal zone B-cells. It probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. SPEN may bind both to DNA and RNA.
  • 细胞定位Nuclear. Associates with chromatin.

SPEN peptide (1503-1517) (ab45877)参考文献

ab45877 has not yet been referenced specifically in any publications.

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