概述

  • 产品名称Anti-SPDEF抗体
    参阅全部 SPDEF 一抗
  • 描述
    小鼠单克隆抗体to SPDEF
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment, corresponding to amino acids 92-201 of Human SPDEF

性能

应用

Our Abpromise guarantee covers the use of ab57042 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 5 µg/ml. This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

靶标

  • 功能May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT-3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter.
  • 组织特异性Expressed in a very restricted set of primarily hormone-regulated epithelial tissues with particularly high expression in the prostate gland. Significantly lower expression is seen in other hormone regulated tissues such as mammary gland, salivary gland, and ovary. Expressed in prostate carcinoma cells.
  • 序列相似性Belongs to the ETS family.
    Contains 1 ETS DNA-binding domain.
    Contains 1 PNT (pointed) domain.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • bA375E1.3 antibody
    • PDEF antibody
    • Prostate derived Ets factor antibody
    • PROSTATE EPITHELIUM SPECIFIC ETS TRANSCRIPTION FACTOR antibody
    • Prostate epithelium-specific Ets transcription factor antibody
    • Prostate specific Ets antibody
    • Prostate-derived Ets factor antibody
    • Prostate-specific Ets antibody
    • PSE antibody
    • RP11-375E1__A.3 antibody
    • SAM POINTED DOMAIN CONTAINING ETS TRANSCRIPTION FACTOR antibody
    • SAM pointed domain-containing Ets transcription factor antibody
    • Spdef antibody
    • SPDEF_HUMAN antibody
    see all

Anti-SPDEF antibody 图像

  • Western blot against tagged recombinant protein immunogen using ab57042 SPDEF antibody at 1ug/ml. Predicted band size of immunogen is 38 kDa

Anti-SPDEF antibody (ab57042)参考文献

This product has been referenced in:
  • Yadav UC  et al. Aldose reductase inhibition prevents metaplasia of airway epithelial cells. PLoS One 5:e14440 (2010). WB ; Human . Read more (PubMed: 21203431) »

See 1 Publication for this product

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