概述

  • 产品名称Anti-SPDEF抗体
    参阅全部 SPDEF 一抗
  • 描述
    兔多克隆抗体to SPDEF
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Synthetic peptide derived from the internal region of human SPDEF.

  • 阳性对照
    • LNCAP prostate carcinoma cell lysates.

性能

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应用

Our Abpromise guarantee covers the use of ab53881 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
ELISA
  • 应用说明Peptide ELISA: Use at a concentration of 0.1 - 1 µg/ml.
    WB: Use at a concentration of 1 - 3 µg/ml. Detects a band of approximately 37 kDa (predicted molecular weight: 37 kDa). A weak band at 55 kDa is also detected which may be due to the glycosylated form of PDEF.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT-3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter.
    • 组织特异性Expressed in a very restricted set of primarily hormone-regulated epithelial tissues with particularly high expression in the prostate gland. Significantly lower expression is seen in other hormone regulated tissues such as mammary gland, salivary gland, and ovary. Expressed in prostate carcinoma cells.
    • 序列相似性Belongs to the ETS family.
      Contains 1 ETS DNA-binding domain.
      Contains 1 PNT (pointed) domain.
    • 细胞定位Nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • bA375E1.3 antibody
      • PDEF antibody
      • Prostate derived Ets factor antibody
      • PROSTATE EPITHELIUM SPECIFIC ETS TRANSCRIPTION FACTOR antibody
      • Prostate epithelium-specific Ets transcription factor antibody
      • Prostate specific Ets antibody
      • Prostate-derived Ets factor antibody
      • Prostate-specific Ets antibody
      • PSE antibody
      • RP11-375E1__A.3 antibody
      • SAM POINTED DOMAIN CONTAINING ETS TRANSCRIPTION FACTOR antibody
      • SAM pointed domain-containing Ets transcription factor antibody
      • Spdef antibody
      • SPDEF_HUMAN antibody
      see all

    Anti-SPDEF antibody (ab53881)参考文献

    This product has been referenced in:
    • Hasnain SZ  et al. Changes in the mucosal barrier during acute and chronic Trichuris muris infection. Parasite Immunol 33:45-55 (2011). IHC ; Mouse . Read more (PubMed: 21155842) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"