概述

  • 产品名称Anti-Spastin抗体
    参阅全部 Spastin 一抗
  • 描述
    小鼠单克隆抗体to Spastin
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment, corresponding to amino acids 200 -305 of Human Spastin (NP_055761) with a proprietary tag

  • 阳性对照
    • Jurkat cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab89449 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 68 kDa.
ELISA Use at an assay dependent dilution.

靶标

  • 相关性Spastin is thought have a role in microtubule dynamics through its function as a microtubule severing protein. It is localised to the centrosome of neuronal cells but is not found in glial cells. Mutation in the ATPase binding domain of spastin causes hereditary spastic paraplegias (HSP), a large group of clinically similar disorders. Mutant forms of spastin are generally found throughout the cytoplasm rather then within the nucleus.
  • 细胞定位Cytoplasm, Cytoskeleton, Endoplasmic reticulum, Endosome, Membrane, Microtubule, Nucleus
  • 数据库链接
  • 别名
    • ADPSP antibody
    • FSP 2 antibody
    • FSP2 antibody
    • KIAA1083 antibody
    • Spast antibody
    • spastic paraplegia 4 (autosomal dominant; spastin) antibody
    • Spastic paraplegia 4 antibody
    • spastin antibody
    • SPG 4 antibody
    • SPG4 antibody
    • SPG4 gene antibody
    see all

Anti-Spastin antibody 图像

  • Anti-Spastin antibody (ab89449) at 1 µg/ml + Recombinant Spastin Protein (Immunogen) at 0.2 µg

    Predicted band size : 68 kDa
    Observed band size : 37 kDa (why is the actual band size different from the predicted?)
  • Anti-Spastin antibody (ab89449) at 1 µg/ml + Jurkat cell lysate at 50 µg

    Predicted band size : 68 kDa
    Observed band size : 68 kDa

Anti-Spastin antibody (ab89449)参考文献

ab89449 has not yet been referenced specifically in any publications.

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