概述

  • 产品名称Anti-SP110抗体
    参阅全部 SP110 一抗
  • 描述
    兔多克隆抗体to SP110
  • 特异性This product recognizes isoforms a, b and c.
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    A 16 amino acid synthetic peptide derived from near the amino terminus of human SP1101. (GenBank accession no. NP_004501, isoform b).

  • 阳性对照
    • SW480 cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab67221 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1 - 2 µg/ml. Detects a band of approximately 80-95 kDa (predicted molecular weight of longest isoform: 79 kDa).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Transcription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes with retinoic acid response elements (RARE).
    • 组织特异性Highly expressed in peripheral blood leukocytes and spleen. Detected at intermediate levels in thymus, prostate, testis, ovary, small intestine and colon, and at low levels in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
    • 疾病相关Defects in SP110 are the cause of hepatic venoocclusive disease with immunodeficiency (VODI) [MIM:235550]. VODI is an autosomal recessive primary immunodeficiency associated with hepatic vascular occlusion and fibrosis. The immunodeficiency is characterized by severe hypogammaglobulinemia, combined T and B cell immunodeficiency, absent lymph node germinal centers, and absent tissue plasma cells.
    • 序列相似性Contains 1 bromo domain.
      Contains 1 HSR domain.
      Contains 1 PHD-type zinc finger.
      Contains 1 SAND domain.
    • 翻译后修饰Phosphorylated (isoform 2).
    • 细胞定位Nucleus. Found in the nuclear body.
    • Information by UniProt
    • 数据库链接
    • 别名
      • FLJ22835 antibody
      • IFI 41 antibody
      • IFI 75 antibody
      • IFI41 antibody
      • IFI75 antibody
      • Interferon induced protein 41 30kD antibody
      • Interferon induced protein 41 antibody
      • Interferon induced protein 41/75 antibody
      • Interferon induced protein 75 52kD antibody
      • Interferon induced protein 75 antibody
      • Interferon-induced protein 41/75 antibody
      • IPR 1 antibody
      • IPR1 antibody
      • Phosphoprotein 41 antibody
      • Phosphoprotein 75 antibody
      • SP 110 antibody
      • SP110 antibody
      • Sp110 nuclear body protein antibody
      • SP110_HUMAN antibody
      • Speckled 110 kDa antibody
      • Transcriptional coactivator Sp110 antibody
      • VODI antibody
      see all

    Anti-SP110 antibody 图像

    • Lane 1 : Anti-SP110 antibody (ab67221) at 1 µg/ml
      Lane 2 : Anti-SP110 antibody (ab67221) at 2 µg/ml

      Lane 1 : SW480 cell lysate
      Lane 2 : SW480 cell lysate

      Lysates/proteins at 15 µg per lane.

      Secondary
      Anti rabbit secondary antibody

      Predicted band size : 79 kDa
      Observed band size : 80-95 kDa (why is the actual band size different from the predicted?)

    Anti-SP110 antibody (ab67221)参考文献

    This product has been referenced in:
    • Molzan M  et al. Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling. Mol Cell Biol 30:4698-711 (2010). Read more (PubMed: 20679480) »

    See 1 Publication for this product

    Product Wall

    Thank you for your enquiry. This product, ab67220 can detect isoform b, and c. Meanwhile, ab67221 can detect isoforms a, b,c.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"