Anti-SP110抗体(ab67220)
Key features and details
- Rabbit polyclonal to SP110
- Suitable for: ICC/IF, WB, IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-SP110抗体
参阅全部 SP110 一抗 -
描述
兔多克隆抗体to SP110 -
宿主
Rabbit -
特异性
This product recognizes isoforms b and c. -
经测试应用
适用于: ICC/IF, WB, IHC-Pmore details -
种属反应性
与反应: Human -
免疫原
A 15 amino acid synthetic peptide derived from near the carboxy terminus of human SP110; (NP_004501.3, SP110 isoform b).
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阳性对照
- Human brain tissue. HeLa cell lysate.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C. -
存储溶液
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab67220于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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ICC/IF | ||
WB | ||
IHC-P |
说明 |
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WB: Use at a concentration of 1 - 2 µg/ml. Detects a band of approximately 63 kDa (predicted molecular weight of isoform b 63kDa, for longest isoform: 79 kDa).
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
靶标
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功能
Transcription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes with retinoic acid response elements (RARE). -
组织特异性
Highly expressed in peripheral blood leukocytes and spleen. Detected at intermediate levels in thymus, prostate, testis, ovary, small intestine and colon, and at low levels in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. -
疾病相关
Defects in SP110 are the cause of hepatic venoocclusive disease with immunodeficiency (VODI) [MIM:235550]. VODI is an autosomal recessive primary immunodeficiency associated with hepatic vascular occlusion and fibrosis. The immunodeficiency is characterized by severe hypogammaglobulinemia, combined T and B cell immunodeficiency, absent lymph node germinal centers, and absent tissue plasma cells. -
序列相似性
Contains 1 bromo domain.
Contains 1 HSR domain.
Contains 1 PHD-type zinc finger.
Contains 1 SAND domain. -
翻译后修饰
Phosphorylated (isoform 2). -
细胞定位
Nucleus. Found in the nuclear body. - Information by UniProt
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数据库链接
- Entrez Gene: 3431 Human
- Omim: 604457 Human
- SwissProt: Q9HB58 Human
- Unigene: 145150 Human
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别名
- FLJ22835 antibody
- IFI 41 antibody
- IFI 75 antibody
see all
图片
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Lane 1 : Anti-SP110 antibody (ab67220) at 0.5 µg/ml
Lane 2 : Anti-SP110 antibody (ab67220) at 1 µg/ml
Lane 3 : Anti-SP110 antibody (ab67220) at 2 µg/ml
All lanes : HeLa cell lysate
Lysates/proteins at 15 µg per lane.
Predicted band size: 63 kDa
Observed band size: 63 kDa -
ab67220 at 2.5µg/ml staining of SP110 in human brain tissue using IHC-P.
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Immunofluorescence of IPR1 in Human Brain cells using ab67220 at 50 ug/ml.
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab67220 尚未被引用在任何文献中。