概述

  • 产品名称Anti-SP110抗体
    参阅全部 SP110 一抗
  • 描述
    山羊多克隆抗体to SP110
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to internal sequence amino acids of Human SP110.

  • 阳性对照
    • Human spleen and tonsil tissues.

性能

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应用

Our Abpromise guarantee covers the use of ab111093 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use a concentration of 3.75 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能Transcription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes with retinoic acid response elements (RARE).
  • 组织特异性Highly expressed in peripheral blood leukocytes and spleen. Detected at intermediate levels in thymus, prostate, testis, ovary, small intestine and colon, and at low levels in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
  • 疾病相关Defects in SP110 are the cause of hepatic venoocclusive disease with immunodeficiency (VODI) [MIM:235550]. VODI is an autosomal recessive primary immunodeficiency associated with hepatic vascular occlusion and fibrosis. The immunodeficiency is characterized by severe hypogammaglobulinemia, combined T and B cell immunodeficiency, absent lymph node germinal centers, and absent tissue plasma cells.
  • 序列相似性Contains 1 bromo domain.
    Contains 1 HSR domain.
    Contains 1 PHD-type zinc finger.
    Contains 1 SAND domain.
  • 翻译后修饰Phosphorylated (isoform 2).
  • 细胞定位Nucleus. Found in the nuclear body.
  • Information by UniProt
  • 数据库链接
  • 别名
    • FLJ22835 antibody
    • IFI 41 antibody
    • IFI 75 antibody
    • IFI41 antibody
    • IFI75 antibody
    • Interferon induced protein 41 30kD antibody
    • Interferon induced protein 41 antibody
    • Interferon induced protein 41/75 antibody
    • Interferon induced protein 75 52kD antibody
    • Interferon induced protein 75 antibody
    • Interferon-induced protein 41/75 antibody
    • IPR 1 antibody
    • IPR1 antibody
    • Phosphoprotein 41 antibody
    • Phosphoprotein 75 antibody
    • SP 110 antibody
    • SP110 antibody
    • Sp110 nuclear body protein antibody
    • SP110_HUMAN antibody
    • Speckled 110 kDa antibody
    • Transcriptional coactivator Sp110 antibody
    • VODI antibody
    see all

Anti-SP110 antibody 图像

  • ab111093, at 3.75µg/ml, staining SP110 in formalin-fixed, paraffin-embedded Human Spleen tissue by Immunohistochemistry.
  • ab111093, at 3.75µg/ml, staining SP110 in formalin-fixed, paraffin-embedded Human Tonsil tissue by Immunohistochemistry.

Anti-SP110 antibody (ab111093)参考文献

ab111093 has not yet been referenced specifically in any publications.

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