概述

  • 产品名称Anti-SP100抗体
    参阅全部 SP100 一抗
  • 描述
    小鼠单克隆抗体to SP100
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment: MAGGGGDLST RRLNECISPV ANEMNHLPAH SHDLQRMFTE DQGVDDRLLY DIVFKHFKRN KVEISNAIKK TFPFLEGLRD RDLITNKMFE DSQDSCRN, corresponding to amino acids 1-99 of Human SP100

性能

应用

Our Abpromise guarantee covers the use of ab58206 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能May play a role in the control of gene expression.
    • 组织特异性Widely expressed. Sp100-B is expressed only in spleen, tonsil, thymus, mature B-cell line and some T-cell line, but not in brain, liver, muscle or non-lymphoid cell lines.
    • 序列相似性Contains 2 HMG box DNA-binding domains.
      Contains 1 HSR domain.
      Contains 1 SAND domain.
    • 结构域The HSR domain is important for the nuclear body targeting as well as for the dimerization.
      Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain.
    • 翻译后修饰Sumoylated. Sumoylation depends on a functional nuclear localization signal but is not necessary for nuclear import or nuclear body targeting.
    • 细胞定位Nucleus > PML body. Found in the nuclear body, also known as nuclear domain 10 (ND10), PML oncogenic domain (POD), nuclear dots (ND) and KR body. The nuclear body is a nucleoplasmic structure of punctate shape, which varies in size and number. Induction by interferon and may be cell cycle stages modulate the subnuclear localization of the isoforms.
    • Information by UniProt
    • 数据库链接
    • 别名
      • DKFZp686E07254 antibody
      • FLJ00340 antibody
      • FLJ34579 antibody
      • Lysp100b antibody
      • Nuclear antigen Sp100 antibody
      • Nuclear autoantigen Sp 100 antibody
      • Nuclear autoantigen Sp-100 antibody
      • Nuclear autoantigen Sp100 antibody
      • Nuclear dot associated Sp100 protein antibody
      • Nuclear dot-associated Sp100 protein antibody
      • SP 100 antibody
      • SP100 antibody
      • SP100 HMG nuclear autoantigen antibody
      • SP100 nuclear antigen antibody
      • SP100_HUMAN antibody
      • Speckled 100 kDa antibody
      see all

    Anti-SP100 antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab58206 SP100 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    Anti-SP100 antibody (ab58206)参考文献

    This product has been referenced in:
    • Schmeisser H  et al. Identification of alpha interferon-induced genes associated with antiviral activity in Daudi cells and characterization of IFIT3 as a novel antiviral gene. J Virol 84:10671-80 (2010). WB ; Human . Read more (PubMed: 20686046) »

    See 1 Publication for this product

    Product Wall

    There are currently no Abreviews or Questions for ab58206.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"