概述

  • 产品名称
  • 描述
    兔多克隆抗体to SOX9
  • 经测试应用
    适用于: ELISA, WB, IHC-P, ICC/IFmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse
  • 免疫原

    Synthetic peptide from an internal sequence of Human SOX9.

  • 阳性对照
    • Human Testis tissues; A549 cells; HEK293 whole cell extract.
  • 常规说明
    Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.

应用

Our Abpromise guarantee covers the use of ab118892 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA Use at an assay dependent concentration. 1/5000
WB 1/500 - 1/1000. Predicted molecular weight: 56 kDa.
IHC-P Use a concentration of 10 µg/ml.
ICC/IF 1/100 - 1/500.

靶标

  • 功能
    Plays an important role in the normal skeletal development. May regulate the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes.
  • 疾病相关
    Defects in SOX9 are the cause of campomelic dysplasia (CMD1) [MIM:114290]. CMD1 is a rare, often lethal, dominantly inherited, congenital osteochondrodysplasia, associated with male-to-female autosomal sex reversal in two-thirds of the affected karyotypic males. A disease of the newborn characterized by congenital bowing and angulation of long bones, unusually small scapulae, deformed pelvis and spine and a missing pair of ribs. Craniofacial defects such as cleft palate, micrognatia, flat face and hypertelorism are common. Various defects of the ear are often evident, affecting the cochlea, malleus incus, stapes and tympanum. Most patients die soon after birth due to respiratory distress which has been attributed to hypoplasia of the tracheobronchial cartilage and small thoracic cage.
  • 序列相似性
    Contains 1 HMG box DNA-binding domain.
  • 细胞定位
    Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • campomelic dysplasia autosomal sex reversal antibody
    • CMD 1 antibody
    • CMD1 antibody
    • CMPD 1 antibody
    • CMPD1 antibody
    • SOX 9 antibody
    • Sox9 antibody
    • SOX9_HUMAN antibody
    • SRA 1 antibody
    • SRA1 antibody
    • SRXX2 antibody
    • SRXY10 antibody
    • SRY (sex determining region Y) box 9 (campomelic dysplasia autosomal antibody
    • SRY (sex determining region Y) box 9 antibody
    • SRY (sex determining region Y)-box 9 antibody
    • SRY (sex-determining region Y)-box 9 protein antibody
    • SRY related HMG box gene 9 antibody
    • Transcription factor SOX 9 antibody
    • Transcription factor SOX-9 antibody
    • transcription factor SOX9 antibody
    see all

图片

  • ab118892 at 10 µg/ml staining SOX9 in Formalin-fixed, Paraffin-embedded Human Testis tissue by Immunohistochemistry.
  • All lanes : Anti-SOX9 antibody (ab118892) at 1/500 dilution

    Lane 1 : HEK293 whole cell extract, treated with PBS 60 minutes
    Lane 2 : HEK293 whole cell extract, treated with PBS 60 minutes with Synthesized peptide


    Predicted band size : 56 kDa
  • ab118892 at 1/100 dilution staining SOX9 in A549 cells by Immunofluorescence. The image on the right is treated with the synthesized peptide.

文献

ab118892 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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