概述

  • 产品名称Anti-SOX3抗体
    参阅全部 SOX3 一抗
  • 描述
    小鼠单克隆抗体to SOX3
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse
  • 免疫原

    Recombinant fragment: KSEPSSPPPA IASHSQRACL GDLRDMISMY LPPGGDAADA ASPLPGGRLH GVHQHYQGAG TAVNGTVPLT H, corresponding to amino acids 375-446 of Human SOX3

性能

应用

Our Abpromise guarantee covers the use of ab55795 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Transcription factor required during the formation of the hypothalamo-pituitary axis. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Required also within the pharyngeal epithelia for craniofacial morphogenesis. Controls a genetic switch in male development. Is necessary for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells.
    • 疾病相关Defects in SOX3 are a cause of panhypopituitarism X-linked (PHPX) [MIM:312000]. Affected individuals have absent infundibulum, anterior pituitary hypoplasia, and ectopic posterior pituitary.
      Defects in SOX3 are the cause of mental retardation X-linked with isolated growth hormone deficiency (MRXGH) [MIM:300123].
      Defects in SOX3 are the cause of 46,XX sex reversal type 3 (SRXX3) [MIM:300833]. A condition in which male gonads develop in a genetic female (female to male sex reversal). Note=Copy number variations (CNV) encompassing or in close proximity to SOX3 are responsible for XX male reversal. These variations include two duplications of approximately 123 kb and 85 kb, the former of which spans the entire SOX3 gene; a 343 kb deletion immediately upstream of SOX3 that is probably responsible of altered regulation (and not increased dosage) of SOX3; a large (approximately 6 Mb) duplication that encompasses SOX3 and at least 18 additional distally located genes. Its proximal breakpoint falls within the SOX3 regulatory region. This large rearrangement has been found in a patient with XX male reversal and a complex phenotype that also includes a scrotal hypoplasia, microcephaly, developmental delay, and growth retardation.
    • 序列相似性Contains 1 HMG box DNA-binding domain.
    • 细胞定位Nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • GHDX antibody
      • MRGH antibody
      • PHP antibody
      • PHPX antibody
      • sox3 antibody
      • SOX3_HUMAN antibody
      • SOXB antibody
      • SRY (sex determining region Y)-box 3 antibody
      • SRY Box 3 antibody
      • SRY-related HMG-box gene 3 antibody
      • Transcription factor Sox-3 antibody
      see all

    Anti-SOX3 antibody 图像



    • Predicted band size : 45 kDa
      SOX3 antibody (ab55795) at 1ug/lane + A-431 cell lysate at 25ug/lane.

    Anti-SOX3 antibody (ab55795)参考文献

    ab55795 has not yet been referenced specifically in any publications.

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