概述

  • 产品名称Anti-SOX2抗体[SP76]
    参阅全部 SOX2 一抗
  • 描述
    兔单克隆抗体[SP76] to SOX2
  • 经测试应用适用于: IHC-P, WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    A synthetic peptide corresponding to N-terminus of Human SOX2 protein.

  • 阳性对照
    • Human newborn brain

应用

Our Abpromise guarantee covers the use of ab93689 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/100. Antigen Retrieval is recommended, boil tissue section in 10mM citrate buffer, pH 6.0 for 10 minutes followed by cooling at RT for 20 minutes.
WB 1/100. Predicted molecular weight: 34 kDa.

靶标

  • 功能Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency.
  • 疾病相关Defects in SOX2 are the cause of microphthalmia syndromic type 3 (MCOPS3) [MIM:206900]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS3 is characterized by the rare association of malformations including uni- or bilateral anophthalmia or microphthalmia, and esophageal atresia with trachoesophageal fistula.
  • 序列相似性Contains 1 HMG box DNA-binding domain.
  • 翻译后修饰Sumoylation inhibits binding on DNA and negatively regulates the FGF4 transactivation.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ANOP3 antibody
    • cb236 antibody
    • Delta EF2a antibody
    • lcc antibody
    • MCOPS3 antibody
    • MGC148683 antibody
    • MGC2413 antibody
    • RGD1565646 antibody
    • Sex determining region Y box 2 antibody
    • SOX 2 antibody
    • Sox2 antibody
    • SOX2_HUMAN antibody
    • SRY (sex determining region Y) box 2 antibody
    • SRY box containing gene 2 antibody
    • SRY related HMG box 2 antibody
    • SRY related HMG box gene 2 antibody
    • SRY-box 2 antibody
    • Transcription factor SOX 2 antibody
    • Transcription factor SOX-2 antibody
    • ysb antibody
    see all

Anti-SOX2 antibody [SP76] 图像

  • Immunohistochemical analysis of Human prostate tissue labelling SOX-2 with ab93689.

  • ab93689 at 1/100 dilution, staining SOX2 in Human newborn brain by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Anti-SOX2 antibody [SP76] (ab93689) at 1/100 dilution + MCF7 cell lysate

    Predicted band size : 34 kDa
    Observed band size : 34 kDa

Anti-SOX2 antibody [SP76] (ab93689)参考文献

ab93689 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab93689.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"