The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at an assay dependent concentration. See Abreview.
1/500. Detects a band of approximately 34 kDa (predicted molecular weight: 34 kDa).
Use at an assay dependent concentration. PubMed: 22741033ab171870-Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody.
功能Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency.
疾病相关Defects in SOX2 are the cause of microphthalmia syndromic type 3 (MCOPS3) [MIM:206900]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS3 is characterized by the rare association of malformations including uni- or bilateral anophthalmia or microphthalmia, and esophageal atresia with trachoesophageal fistula.
序列相似性Contains 1 HMG box DNA-binding domain.
翻译后修饰Sumoylation inhibits binding on DNA and negatively regulates the FGF4 transactivation.
Anti-SOX2 antibody (ab69893) at 1/500 dilution + normal human brain lysate at 10 µg
Predicted band size : 34 kDa Observed band size : 34 kDa
Anti-SOX2 antibody (ab69893)参考文献
This product has been referenced in:
Donovan LK et al. A Prominin-1-Rich Pediatric Glioblastoma: Biologic Behavior Is Determined by Oxygen Tension-Modulated CD133 Expression but Not Accompanied by Underlying Molecular Profiles. Transl Oncol5:141-54 (2012).
ICC/IF, Flow Cyt
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